THE LAB

The Bonventre Lab is dedicated to rigorous, interdisciplinary research to create innovative technologies and treatments in the fight against kidney  disease,  and to uncovering the mechanisms and  pathologies  involved in kidney injury and repair.  Led by Joseph V Bonventre, MD, PhD, a world leader in nephrology for over 40 years, the lab fosters an environment of inquiry, integrity and growth.  The lab has continuously inspired and supported researchers at all levels, and has produced numerous academic and clinical leaders who shape the study and treatment of kidney disease worldwide.

DR. BONVENTRE

Dr. Joseph Bonventre is one of the most influential physician scientists of his generation.

He is Chief of the Division of Renal Medicine and Founding Chief of the Engineering in Medicine Division at Brigham and Women’s Hospital, Past-President of the American Society of Nephrology. He led the Kidney Health Initiative Roadmap Initiative for innovative approaches to kidney replacement therapy. He has trained over 150 individuals in his laboratory, many of whom have assumed leadership positions in science and academic medicine. For five years he was Associate Director and for 10 years the Harvard Director of the Harvard-MIT Division of Health Sciences and Technology, where he was responsible for the MD, MD-PhD or PhD training of more than 500 individuals.  He was named one of the three top mentors in the U.S. by postdoctoral fellows in the journal Science in 2004. His laboratory generated a protocol for direct differentiation of kidney organoids from human stem cells that is widely used. His lab has a great deal of experience with various animal models of AKI and chronic kidney disease and discovered KIM-1, a widely used biomarker of kidney injury. The lab also identified cell cycle arrest and the subsequent senescence response of the cell as a key mediator of the transition of acute injury to chronic fibrotic kidney disease. The lab’s work has been cited more than 69,000 times (>26,800 since 2015) and Dr. Bonventre has a citation h-index of 133. He was identified as the most  cited investigator in the field of acute kidney injury and is #4 on the list of  world’s top 2% of scientists by Stanford University in the area of Urology and Nephrology.

See Dr. Bonventre’s full profile here

RESEARCH

kidcanva

A major focus of the laboratory has been the study of the pathophysiology of acute renal failure and processes involved with repair. There are many parallels between repair and the normal development of the kidney. While repair is generally considered to be adaptive it can be maladaptive, especially when the acute injury is superimposed on chronic kidney disease. 

cellcanva

The kidney possesses the intrinsic capacity for repair after injury but whether adult kidney stem cells are responsible for epithelial regeneration is unresolved. During nephrogenesis, renal epithelia develop from precursors located in the metanephric mesenchyme that condense to form the nephron. 

molcanva

Reliance on current measures of renal dysfunction, such as serum creatinine and blood urea nitrogen, has contributed to the slow translation of basic science discovery to therapeutically effective approaches in clinical practice. 

PUBLICATIONS

2021

2020

 
 

NEWS

February 15-19, 2021

Congratulations to Li-Li Hsiao on her appointment by the International Society of Nephrology (ISN) to represent the North America and Caribbean region as a Member of the World Kidney Day Steering Committee

Congratulations also to Luke Lee on his publication “Exosome detection via the ultrafast-isolation system: EXODUS” being featured on the cover of this month’s Nature Methods. The EXODUS system will be very useful for many applications including urine-based molecular diagnostics and purifying EV for therapeutics. A copy of the article is attached and a link is here: https://www.nature.com/articles/s41592-020-01034-x.

Simon Correa and Finnian Mc Causland have just published an editorial entitled “Leveraging Deep Learning to Improve Safety of Outpatient Hemodialysis” in CJASN, commenting on the potential of machine learning to improve dialysis safety through real time assessments. They comment on a paper by Lee et.al. entitled “Deep Learning Model for Real-Time Prediction of Intradialytic Hypotension.” A link to their editorial is here: https://cjasn.asnjournals.org/content/early/2021/02/10/CJN.00450121.