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Joseph V. Bonventre, M.D., Ph.D

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Current Areas of Research

Dr. Bonventre’s research focuses primarily on the study of kidney injury and repair and signal transduction, with a special emphasis on the role of inflammation, biomarkers and stem cells.

Education and Professional Training

Cornell University, Ithaca, NY, BS with distinction: Engineering Physics, 1970.

Harvard Medical School (HMS/MIT Division HST), MD Medicine, 1976.

Harvard University, PhD Biophysics, 1979.

Honors

1987-1992: Established Investigator, American Heart Association

1987-present: American Society for Clinical Investigation

1989-95: Associate Editor, American Journal of Physiology:Renal; 1999- Asso. Editor, Cell & Tissue Res.

1988-1992: American Heart National Review Board; 1992, Ad hoc Member, NIH Path A Study Section

1993: Association of American Physicians; 1998, Am. Institute for Medical and Biological Engineering

1993-2001: MERIT award, NIDDK, NIH

1998-present: Board of Directors, National Space Biology Research Institute

2003-present: Board of Advisors, Dean, School of Engineering, Cornell University

2005-present: Director of Kidney Group, Harvard Stem Cell Initiative

Original Articles
  1. Bonventre JV, Huang Z, Taheri MR, O’Leary E, Li E, Moskowitz MA, Sapirstein A. Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature 390:622-25, 1997.
  2. Gray ML, Bonventre JV. Training PhD researchers to translate science to clinical medicine: closing the gap from the other side. Nature Medicine 5:433-6. 2002
  3. Auchincloss H, Bonventre JV. Transplanting cloned cells into therapeutic promise. Nature Biotechnol. 20:665-6, 2002
  4. Haq S, Kilter H, Michael A, Tao J, O’Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Guerrero JL, Andreucci M, Cui L, Rosenzweig A, Molkentin J, Liao R, Patten R, Picard M, Bonventre JV, Force T: Deletion of cytosolic phospholipase A2 promotes striated muscle growth. Nature Medicine 9:944-51, 2003
  5. Andreucci M, Michael A, Kramers C, Park KM, Chen A, Matthaeus T, Alessandrini A, Haq S, Force T, Bonventre JV. Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int. 64:1189-98, 2003.
  6. Ichimura T, Hung CC, Yang SA, Stevens JL, Bonventre JV. Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol. 286:F552-63, 2004
  7. Bonventre JV, Zuk A. Ischemic acute renal failure: an inflammatory disease? Kidney Int. 66:480-5, 2004
  8. Sim KG, Zang Z, Yang CM, Bonventre JV, Hsu SI. TRIP-Br links E2F to novel functions in the regulation of cyclin e expression during cell cycle progression and in the maintenance of genomic stability. Cell Cycle. 3:1296-304, 2004
  9. Han WK, Bonventre JV. Biologic markers for the early detection of acute kidney injury. Curr Opin Crit Care.10:476-482, 2004
  10. Park KM, Kim JI, Ahn Y, Bonventre AJ, Bonventre JV Testosterone Is Responsible for Enhanced Susceptibility of Males to Ischemic Renal Injury J. Biol. Chem. 279, 52282-52292, 2004
  11. Hentschel DM, Park KM, Cilenti L, Zervos AS, Drummond I, Bonventre JV Acute Renal Failure in Zebrafish - A Novel System to Study a Complex Disease. Am J Physiol Renal Physiol. 288: F923-9, 2005
  12. Jaber BL, Pereira BJ, Bonventre JV, Balakrishnan VS Polymorphism of host response genes: Implications in the pathogenesis and treatment of acute renal failure. Kidney Int. 67:14-33, 2005
  13. Cilenti L, Kyriazis GA, Soundarapandian MM, Stratico V, Yerkes A, Park KM, Sheridan AM, Alnemri ES, Bonventre JV, Zervos AS. Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells. Am J Physiol Renal Physiol. 288:F371-9, 2005
  14. Sapirstein A, Saito H, Texel S, Samad T, O’leary E, Bonventre JV. Cytosolic phospholipase A2a regulates induction of brain cyclooxygenase-2 In a mouse model of inflammation Am J Physiol Regul Integr Comp Physiol. 288:R1774-82, 2005
  15. Ilsley JN, Nakanishi M, Flynn C, Belinsky GS, De Guise S, Adib JN, Dobrowsky RT, Bonventre JV, Rosenberg DW. Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis. Cancer Res. 65:2636-43, 2005
  16. Muckova K, Duffield JS, Held KD, Bonventre JV, Sheridan AM. cPLA2-interacting protein, PLIP, causes apoptosis and decreases G1 phase in mesangial cells. Am J Physiol Renal Physiol. 290(1):F70-9, 2005
  17. Hentschel DM, Bonventre JV..Novel non-rodent models of kidney disease. Curr Mol Med. 5:537-46, 2005
  18. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol.16:3365-70, 2005
  19. Duffield JS, Bonventre JV. Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injury. Kidney Int. 68:1956-61, 2005
  20. Duffield JS, Tipping PG, Kipari T, Cailhier JF, Clay S, Lang R, Bonventre JV, Hughes J. Conditional ablation of macrophages halts progression of crescentic glomerulonephritis. Am J Path. 167:1207-19, 2005
  21. Park KM, Cho HJ, Bonventre JV. Orchiectomy reduces susceptibility to renal ischemic injury: a role for heat shock proteins. Biochem Biophys Res Commun. 328:312-7, 2005
  22. Han WK, Alinani A, Wu CL, Michaelson D, Loda M, McGovern FJ, Thadhani R, Bonventre JV. Human Kidney Injury Molecule-1 Is a Tissue and Urinary Tumor Marker of Renal Cell Carcinoma. J.Am.Soc Neph 16: 1126-34, 2005
  23. Duffield JS, Park K-M, Hsiao L-L, Kelley V, Scadden DT, Ichimura T, Bonventre JV. Regeneration of tubular epithelial cells during repair of the ischemically injured kidney is independent of bone marrow stem cells. J. Clin. Invest. 115:1743-1755, 2005
  24. Vaidya VS, Ramirez V, Ichimura T, Bobadilla NA, Bonventre JV. Urinary kidney injury molecule-1 (Kim-1): a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol. 290:F517-29, 2006
  25. van Timmeren MM, Bakker SJ, Vaidya VS, Bailly V, Schuurs TA, Damman J, Stegeman CA, Bonventre JV, van Goor H. Tubular Kidney Injury Molecule-1 (Kim-1) In Protein-Overload Nephropathy. Am J Physiol Renal Physiol. 291:F456-464, 2006
  26. Stafforini DM, Sheller JR, Blackwell TS, Sapirstein A, Yull FE, McIntyre TM, Bonventre JV, Prescott SM, Roberts LJ 2nd. Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J Biol Chem. 281: 4616-23, 2006
  27. Kim J, Kil IS, Seok YM, Yang ES, Kim DK, Lim DG, Park JW, Bonventre JV, Park KM. Orchiectomy attenuates post-ischemic oxidative stress and ischemia/reperfusion injury in mice. A role for manganese superoxide dismutase. J Biol Chem 281:20349-56, 2006
  28. Kang MS, Jeong JY, Seo JH, Jeon HJ, Jung KM, Chin MR, Moon CK, Bonventre JV, Jung SY, Kim DK. Methylmercury-induced toxicity is mediated by enhanced intracellular calcium through activation of phosphatidylcholine-specific phospholipase C. Toxicol Appl Pharmacol 216:206-215, 2006
  29. Balestrieri B, Hsu VW, Gilbert H, Leslie CC, Han WK, Bonventre JV, Arm JP. Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis. J. Biol. Chem. 281:6691-8 2006
  30. Rennert PD, Ichimura T, Sizing ID, Bailly V, Li Z, Rennard R, McCoon P, Pablo L, Miklasz S, Tarilonte L, Bonventre JV. TIM-2 gene-deficient mice reveal a novel mechanism for the regulation of TH2 immune responses and airway inflammation. J. Immunology 177: 4311-4321, 2006
  31. Vaidya VS and Bonventre JV. Mechanistic biomarkers for cytotoxic acute kidney injury. Expert Opin Drug Metab Toxicol 2: 697-713, 2006
  32. Lin F, Zhang PL, Yang XJ, Blasick, TM, Han WK, Shen SS, Bonventre JV. Human kidney injury molecule-1 (hKIM-1): a useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma. Am. J. Surg. Pathology In Press
  33. Duffield JS, Hong S, Vaidya V, Lu Y, Fredman G, Serhan CN, Bonventre JV. Resolvin D Series and Protectin D1 Mitigate Acute Kidney Injury. J. Immunology 177:5902-11, 2006

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