Takaharu Ichimura, Ph.D

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Current Areas of Research
  • Mechanism of renal epithelial injury and repair in acute kidney injury.
  • Function of Kidney Injury Molecule –1 (KIM-1) in epithelial regeneration and differentiation.
  • Function of Glycoprotein NMB (GPNMB) in activated macrophages during inflammatory responses and embryonic development.
  • Mechanism of Endoplasmic Reticulum mediated cytoprotection against toxic chemicals.
Education and Professional Training

Tokyo Metropolitan University, B.S. Chemistry, 1988.

Clarkson University, Ph.D Chemistry, 1995.

Original Articles
  1. Matsuda, R., N. Noro and T. Ichimura (1988) Myoblast mediated fusion injection: A new technique for introduction of macromolecules specifically into living skeletal muscle cells. Exp. Cell Res. 176:366-370.

  2. Zhang, G., T. Ichimura, A. Wallin, M. Kan and J.L. Stevens (1991) Regulation of rat proximal tubule epithelial cell growth by fibroblast growth factors, insulin-like growth factor-1 and transforming growth factor-b and analysis of fibroblast growth factors in rat kidney. J. Cell. Physiol. 148:295-305.

  3. Hayden, P.J., T. Ichimura, D.J. McCann, L.R. Pohl and J.L. Stevens (1991) Cross-reactivity of halothane adduct antibodies with cysteine conjugate adducts: in vivo adduct formation with specific mitochondrial proteins and implications for immune-mediated toxicities. J. Biol. Chem. 266:18415-18418.

  4. Zhang, G., T. Ichimura, J.A.M. Maier, T. Maciag and J.L. Stevens (1993) A role for fibroblast growth factor type-1 in nephrogenic repair: autocrine expression in rat kidney proximal tubule epithelial cells in vitro and in the regenerating epithelium following nephrotoxic damage by S-(1,1,2,2-tetrafluoroethyl)-L-cysteine in vivo. J. Biol. Chem. 268:11542-11547.

  5. Zhang, G., J.D. Sato, M.T. Herley, M.W.-K. Tsang, H. Ye, H. Liu, T. Ichimura, G. Yan, W.L. McKeehan and J.L. Stevens (1994) Stable and temperature sensitive transformation of rat kidney epithelial cells suppresses expression of acidic fibroblast growth factor (FGF-1) but activates secretion of FGF-3 (Int-2) and vascular endothelial growth factor (VEGF). Cell Growth Diff. 5:349-357.

  6. Ichimura, T., J.A.-M. Maier, T. Maciag, G. Zhang and J.L. Stevens (1995) Fibroblast growth factor-1 (acidic FGF) in normal and regenerating kidney: expression in mononuclear, interstitial and regenerating epithelial cells. Am. J. Physiol. 269:F653-F662.

  7. Ichimura, T., P.W. Finch, G. Zhang, M. Kan and J.L. Stevens (1996) Induction of FGF-7 after kidney damage: a possible paracrine mechanism for tubule repair. Am. J. Physiol. 271:F967-F976.

  8. Ichimura, T., J.V. Bonventre, V. Bailly, H. Wei, C.A. Hession, R.L. Cate and M. Sanicola (1998) Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel Ig domain, is unregulated in renal cells after injury. J. Biol. Chem. 273:4135-4142.

  9. Hung CC, Ichimura T, Stevens JL, Bonventre JV. (2003) Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation. J Biol Chem. 278:29317-26.

  10. Ichimura T, Hung CC, Yang SA, Stevens JL, Bonventre JV. (2004) Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol. 286:F552-63.

  11. Duffield JS, Park K-M, Hsiao L-L, Kelley V, Scadden DT, Ichimura T, Bonventre JV. (2005) Regeneration of tubular epithelial cells during repair of the ischemically injured kidney is independent of bone marrow stem cells. J. Clin. Invest. 115(7): 1743-55.

  12. Schachter AD, Ichimura T, Kohane IS. (2005) Chromosomes 18 and X are quantitative trait loci for nephrotic-range proteinuria in rats. Pediatr Nephrol. 20(12): 1717-23.

  13. Asmellash S, Stevens JL, Ichimura T. (2005) Modulating the Endoplasmic Reticulum Stress Response with trans-4,5-Dihydroxy-1,2-dithiane Prevents Chemically-Induced Renal Injury in vivo. Toxicol Sci. 88(2): 576-84.

  14. Vaidya VS, Ramirez V, Ichimura T, Bobadilla NA, Bonventre JV. (2005) Urinary kidney injury molecule-1 (Kim-1): a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol. 2006 290(2): F517-29.

  15. Rennert PD, Ichimura T, Sizing ID, Bailly V, Li Z, Rennard R, McCoon P, Pablo L, Miklasz S, Tarilonte L, Bonventre JV. T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. J Immunol. 2006 177:4311-21.

Reviews/Chapters/Editorials
  1. Ichimura T, Bonventre JV. Growth factors, signaling, and renal injury and repair. Militoris BA, Finn WF eds, Acute Renal Failure, Saunders, 2001: 101-118.

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