Patricio Downey, MD

We worked with Adam Sapirstein in constructing a plasmid that over expressed anti-apoptotic molecule blc2 in cels. that expressed constitutively cPLA2. We were looking if they were more resistant to die. We did not probe it. Then I moved to work with ko mice for cPLA2 studying their renal phenotype. We found that, though they have normal almost normal renal function rate they cannot concentrate urine and express less renal aquaporins. That work was reported in Am J Physiol Renal Physiol 2001 Apr;280(4):F607-18.