2010-2019

PUBLICATIONS

2019

Davidsohn N, Pezone M, Vernet A, Graveline A, Oliver D, Slomovic S, Punthambaker S, Sun X, Liao R, Bonventre JV, Church GM. A single combination gene therapy treats multiple age-related diseases. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23505-23511. doi: 10.1073/pnas.1910073116. Epub 2019 Nov 4. Erratum in: Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):790. PMID: 31685628; PMCID: PMC6876218

Kishi S, Brooks CR, Taguchi K, Ichimura T, Mori Y, Akinfolarin A, Gupta N, Galichon P, Elias BC, Suzuki T, Wang Q, Gewin L, Morizane R, Bonventre JV. Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses. J Clin Invest. 2019 Nov 1;129(11):4797-4816. doi: 10.1172/JCI122313. PMID: 31589169; PMCID: PMC6819104.

Bonventre JV, Hurst FP, West M, Wu I, Roy-Chaudhury P, Sheldon M. A Technology Roadmap for Innovative Approaches to Kidney Replacement Therapies: A Catalyst for Change. Clin J Am Soc Nephrol. 2019 Oct 7;14(10):1539-1547. doi: 10.2215/CJN.02570319. Epub 2019 Sep 27. PMID: 31562182; PMCID: PMC6777588.

Zhang X, Zhou Y, Yu X, Huang Q, Fang W, Li J, Bonventre JV, Sukhova GK, Libby P, Shi GP. Differential Roles of Cysteinyl Cathepsins in TGF-β Signaling and Tissue Fibrosis. iScience. 2019 Sep 27;19:607-622. doi: 10.1016/j.isci.2019.08.014. Epub 2019 Aug 9. PMID: 31446224; PMCID: PMC6715892.

Capasso A, Benigni A, Capitanio U, Danesh FR, Di Marzo V, Gesualdo L, Grandaliano G, Jaimes EA, Malyszko J, Perazella MA, Qian Q, Ronco P, Rosner MH, Trepiccione F, Viggiano D, Zoccali C, Capasso G; International Conference on Onco-Nephrology Participants. Summary of the International Conference on Onco-Nephrology: an emerging field in medicine. Kidney Int. 2019 Sep;96(3):555-567. doi: 10.1016/j.kint.2019.04.043. Epub 2019 May 31. PMID: 31445584.

Rao VS, Ahmad T, Brisco-Bacik MA, Bonventre JV, Wilson FP, Siew ED, Felker GM, Anstrom KK, Mahoney DD, Bart BA, Tang WHW, Velazquez EJ, Testani JM. Renal Effects of Intensive Volume Removal in Heart Failure Patients With Preexisting Worsening Renal Function. Circ Heart Fail. 2019 Jun;12(6):e005552. doi: 10.1161/CIRCHEARTFAILURE.118.005552. Epub 2019 Jun 5. PMID: 31163974; PMCID: PMC6585463.

Docherty MH, O’Sullivan ED, Bonventre JV, Ferenbach DA. Cellular Senescence in the Kidney. J Am Soc Nephrol. 2019 May;30(5):726-736. doi: 10.1681/ASN.2018121251. Epub 2019 Apr 18. PMID: 31000567; PMCID: PMC6493983

Zuk A, Bonventre JV. Recent advances in acute kidney injury and its consequences and impact on chronic kidney disease. Curr Opin Nephrol Hypertens. 2019 Jul;28(4):397-405. doi: 10.1097/MNH.0000000000000504. PMID: 30925515; PMCID: PMC7020661

Homan KA, Gupta N, Kroll KT, Kolesky DB, Skylar-Scott M, Miyoshi T, Mau D, Valerius MT, Ferrante T, Bonventre JV, Lewis JA, Morizane R. Flow-enhanced vascularization and maturation of kidney organoids in vitro. Nat Methods. 2019 Mar;16(3):255-262. doi: 10.1038/s41592-019-0325-y. Epub 2019 Feb 11. PMID: 30742039; PMCID: PMC6488032.

Canaud G, Brooks CR, Kishi S, Taguchi K, Nishimura K, Magassa S, Scott A, Hsiao LL, Ichimura T, Terzi F, Yang L, Bonventre JV. Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive. repair. Sci Transl Med. 2019 Jan 23;11(476):eaav4754. doi: 10.1126/scitranslmed.aav4754. PMID: 30674655; PMCID: PMC6527117

Chappell JC, Turner PK, Pak YA, Bacon J, Chiang AY, Royalty J, Hall SD, Kulanthaivel P, Bonventre JV. Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195. doi: 10.1002/cpt.1296. Epub 2018 Dec 30. PMID: 30449032; PMCID: PMC6465099

2018

Liu L, Bonventre JV, Rittenhouse AR. cPLA2α-/- sympathetic neurons exhibit increased membrane excitability and loss of N-Type Ca2+ current inhibition by M1 muscarinic receptor signaling. PLoS One. 2018 Dec 17;13(12):e0201322. doi: 10.1371/journal.pone.0201322. PMID: 30557348; PMCID: PMC6296557

Bonventre JV. Kidney organoids-a new tool for kidney therapeutic development. Kidney Int. 2018 Dec;94(6):1040-1042. doi: 10.1016/j.kint.2018.07.029. PMID: 30466559

Chappell JC, Turner PK, Pak YA, Bacon J, Chiang AY, Royalty J, Hall SD, Kulanthaivel P, Bonventre JV. Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195. doi: 10.1002/cpt.1296. Epub 2018 Dec 30. PMID: 30449032; PMCID: PMC6465099

Barasch J, Zager R, Bonventre JV. The definition of acute kidney injury -Authors’ reply. Lancet. 2018 Jan 20;391(10117):203-204. doi: 10.1016/S0140-6736(17)31626-4. PMID: 30277885

Hill SJ, Decker B, Roberts EA, Horowitz NS, Muto MG, Worley MJ Jr, Feltmate CM, Nucci MR, Swisher EM, Nguyen H, Yang C, Morizane R, Kochupurakkal BS, Do KT, Konstantinopoulos PA, Liu JF, Bonventre JV, Matulonis UA, Shapiro GI, Berkowitz RS, Crum CP, D’Andrea AD. Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids. Cancer Discov. 2018 Nov;8(11):1404-1421. doi: 10.1158/2159-8290.CD-18-0474. Epub 2018 Sep 13. PMID: 30213835; PMCID: PMC6365285

Leon J, Pérez-Sáez MJ, Uffing A, Murakami N, Watanabe A, Cureton P, Kenyon V, Keating L, Yee K, Fernandes Satiro CA, Yu B, Bonventre JV, Fasano A, Riella LV. Effect of Combined Gluten-Free, Dairy-Free Diet in Children With Steroid- Resistant Nephrotic Syndrome: An Open Pilot Trial. Kidney Int Rep. 2018 Mar 3;3(4):851-860. doi: 10.1016/j.ekir.2018.02.011. PMID: 30116795; PMCID: PMC6093178

Yin W, Zhang PL, Macknis JK, Lin F, Bonventre JV. Kidney injury molecule-1 identifies antemortem injury in postmortem adult and fetal kidney. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1637-F1643. doi: 10.1152/ajprenal.00060.2018. Epub 2018 Aug 15. PMID: 30110569; PMCID: PMC6337001
Gupta N, Susa K, Yoda Y, Bonventre JV, Valerius MT, Morizane R. CRISPR/Cas9-based Targeted Genome Editing for the Development of Monogenic Diseases Models with Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2018 May;45(1):e50. doi: 10.1002/cpsc.50. Epub 2018 Apr 26. PMID: 30040245; PMCID: PMC6060633

Scelo G, Muller DC, Riboli E, Johansson M, Cross AJ, Vineis P, Tsilidis KK, Brennan P, Boeing H, Peeters PHM, Vermeulen RCH, Overvad K, Bueno-de-Mesquita HB, Severi G, Perduca V, Kvaskoff M, Trichopoulou A, La Vecchia C, Karakatsani A, Palli D, Sieri S, Panico S, Weiderpass E, Sandanger TM, Nøst TH, Agudo A, Quirós JR, Rodríguez-Barranco M, Chirlaque MD, Key TJ, Khanna P, Bonventre JV, Sabbisetti VS, Bhatt RS. KIM-1 as a Blood-Based Marker for Early Detection of Kidney Cancer: A Prospective Nested Case-Control Study. Clin Cancer Res. 2018 Nov 15;24(22):5594-5601. doi: 10.1158/1078-0432.CCR-18-1496. Epub 2018 Jul 23. PMID: 30037816; PMCID: PMC6239904

Waikar SS, Rebholz CM, Zheng Z, Hurwitz S, Hsu CY, Feldman HI, Xie D, Liu KD, Mifflin TE, Eckfeldt JH, Kimmel PL, Vasan RS, Bonventre JV, Inker LA, Coresh J; Chronic Kidney Disease Biomarkers Consortium Investigators. Biological Variability of Estimated GFR and Albuminuria in CKD. Am J Kidney Dis. 2018 Oct;72(4):538-546. doi: 10.1053/j.ajkd.2018.04.023. Epub 2018 Jul 18. PMID: 30031564; PMCID: PMC6469385

Lei C, Berra L, Rezoagli E, Yu B, Dong H, Yu S, Hou L, Chen M, Chen W, Wang H, Zheng Q, Shen J, Jin Z, Chen T, Zhao R, Christie E, Sabbisetti VS, Nordio F, Bonventre JV, Xiong L, Zapol WM. Nitric Oxide Decreases Acute Kidney Injury and. Stage 3 Chronic Kidney Disease after Cardiac Surgery. Am J Respir Crit Care Med. 2018 Nov 15;198(10):1279-1287. doi: 10.1164/rccm.201710-2150OC. PMID: 29932345; PMCID: PMC6290943

Yu SM, Bonventre JV. Acute Kidney Injury and Progression of Diabetic KidneyDisease. Adv Chronic Kidney Dis. 2018 Mar;25(2):166-180. doi: 10.1053/j.ackd.2017.12.005. PMID: 29580581; PMCID: PMC5898826

Zuk A, Palevsky PM, Fried L, Harrell FE Jr, Khan S, McKay DB, Devey L, Chawla L, de Caestecker M, Kaufman JS, Thompson BT, Agarwal A, Greene T, Okusa MD, Bonventre JV, Dember LM, Liu KD, Humphreys BD, Gossett D, Xie Y, Norton JM, Kimmel PL, Star RA. Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop. Clin J Am Soc Nephrol. 2018 Jul 6;13(7):1113-1123. doi: 10.2215/CJN.06820617. Epub 2018 Mar 9. PMID: 29523680; PMCID: PMC6032575

Nowak N, Skupien J, Smiles AM, Yamanouchi M, Niewczas MA, Galecki AT, Duffin KL, Breyer MD, Pullen N, Bonventre JV, Krolewski AS. Markers of early progressive renal decline in type 2 diabetes suggest different implications for etiological studies and prognostic tests development. Kidney Int. 2018 May;93(5):1198-1206. doi: 10.1016/j.kint.2017.11.024. Epub 2018 Feb 2. PMID: 29398132; PMCID: PMC5911430

Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O’Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM. Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury. Circulation. 2018 May 8;137(19):2016-2028. doi: 10.1161/CIRCULATIONAHA.117.030112. Epub 2018 Jan 19. Erratum in: Circulation. 2018 Jun 19;137(25):e853. PMID: 29352071; PMCID: PMC6066176

Song CY, Khan NS, Liao FF, Wang B, Shin JS, Bonventre JV, Malik KU. Brain Cytosolic Phospholipase A2α Mediates Angiotensin II-Induced Hypertension and Reactive Oxygen Species Production in Male Mice. Am J Hypertens. 2018 Apr
13;31(5):622-629. doi: 10.1093/ajh/hpy009. PMID: 29342227; PMCID: PMC5905655

Emerson SC, Waikar SS, Fuentes C, Bonventre JV, Betensky RA. Biomarker validation with an imperfect reference: Issues and bounds. Stat Methods Med Res. 2018 Oct;27(10):2933-2945. doi: 10.1177/0962280216689806. Epub 2017 Feb 6. PMID: 28166709; PMCID: PMC5494007.

Ismail OZ, Sriranganathan S, Zhang X, Bonventre JV, Zervos AS, Gunaratnam L. Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis. J Cell Physiol. 2018 Oct;233(10):6877-6895. doi: 10.1002/jcp.26578. Epub 2018 Apr 25. PMID: 29693725; PMCID: PMC6066178

Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS. Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis. J Am Soc Nephrol. 2018 Jun;29(6):1690-1705. doi: 10.1681/ASN.2017121283. Epub 2018 May 8. PMID: 29739813; PMCID: PMC6054344

2017

Pollock C, Zuk A, Anders HJ, Ganji MR, Johnson DW, Kasiske B, Langham RG, Pecoits-Filho R, Remuzzi G, Rossert J, Suzuki Y, Tanaka T, Walker R, Yang CW, Bonventre JV. The establishment and validation of novel therapeutic targets to retard progression of chronic kidney disease. Kidney Int Suppl (2011). 2017 Oct;7(2):130-137. doi: 10.1016/j.kisu.2017.07.008. Epub 2017 Sep 20. PMID: 30675427; PMCID: PMC6341008

Yonker LM, Pazos MA, Lanter BB, Mou H, Chu KK, Eaton AD, Bonventre JV, Tearney GJ, Rajagopal J, Hurley BP. Neutrophil-Derived Cytosolic PLA2α Contributes to Bacterial-Induced Neutrophil Transepithelial Migration. J Immunol. 2017 Oct 15;199(8):2873-2884. doi: 10.4049/jimmunol.1700539. Epub 2017 Sep 8. PMID: 28887431; PMCID: PMC5636676

Morizane R, Miyoshi T, Bonventre JV. Concise Review: Kidney Generation with Human Pluripotent Stem Cells. Stem Cells. 2017 Nov;35(11):2209-2217. doi: 10.1002/stem.2699. Epub 2017 Sep 26. PMID: 28869686; PMCID: PMC5805143

Bhowmick R, Clark S, Bonventre JV, Leong JM, McCormick BA. Cytosolic Phospholipase A₂α Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection. Infect Immun. 2017 Oct 18;85(11):e00280-17. doi: 10.1128/IAI.00280-17. PMID: 28808157; PMCID: PMC5649009

Pazos MA, Lanter BB, Yonker LM, Eaton AD, Pirzai W, Gronert K, Bonventre JV, Hurley BP. Pseudomonas aeruginosa ExoU augments neutrophil transepithelial migration. PLoS Pathog. 2017 Aug 3;13(8):e1006548. doi: 10.1371/journal.ppat.1006548. PMID: 28771621; PMCID: PMC5557605

Yamanouchi M, Skupien J, Niewczas MA, Smiles AM, Doria A, Stanton RC, Galecki AT, Duffin KL, Pullen N, Breyer MD, Bonventre JV, Warram JH, Krolewski AS. Improved clinical trial enrollment criterion to identify patients with diabetes at risk of end-stage renal disease. Kidney Int. 2017 Jul;92(1):258-266. doi: 10.1016/j.kint.2017.02.010. Epub 2017 Apr 7. PMID: 28396115; PMCID: PMC5796779

Humanes B, Camaño S, Lara JM, Sabbisetti V, González-Nicolás MÁ, Bonventre JV, Tejedor A, Lázaro A. Cisplatin-induced renal inflammation is ameliorated by cilastatin nephroprotection. Nephrol Dial Transplant. 2017 Oct 1;32(10):1645-1655. doi: 10.1093/ndt/gfx005. PMID: 28340076; PMCID: PMC6251639

Park M, Hsu CY, Go AS, Feldman HI, Xie D, Zhang X, Mifflin T, Waikar SS, Sabbisetti VS, Bonventre JV, Coresh J, Nelson RG, Kimmel PL, Kusek JW, Rahman M, Schelling JR, Vasan RS, Liu KD; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators; CKD Biomarkers Consortium. Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study. Clin J Am Soc Nephrol. 2017 May 8;12(5):761-771. doi: 10.2215/CJN.08560816. Epub 2017 Mar 2. PMID: 28254771; PMCID: PMC5477212

Barasch J, Zager R, Bonventre JV. Acute kidney injury: a problem of definition. Lancet. 2017 Feb 25;389(10071):779-781. doi: 10.1016/S0140-6736(17)30543-3. PMID: 28248160; PMCID: PMC5460771

Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Zhang L, Kyttaris VC, Tsokos GC, Stillman IE, Ichimura T, Bonventre JV, Libby P, Shi GP. CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol. 2017 Apr 1;198(7):2568-2577. doi: 10.4049/jimmunol.1600028. Epub 2017 Feb 20. PMID: 28219888; PMCID: PMC5360510

Morizane R, Bonventre JV. Kidney Organoids: A Translational Journey. Trends Mol Med. 2017 Mar;23(3):246-263. doi: 10.1016/j.molmed.2017.01.001. Epub 2017 Feb 7. PMID: 28188103; PMCID: PMC5442988

Emerson SC, Waikar SS, Fuentes C, Bonventre JV, Betensky RA. Biomarker validation with an imperfect reference: Issues and bounds. Stat Methods Med Res. 2018 Oct;27(10):2933-2945. doi: 10.1177/0962280216689806. Epub 2017 Feb 6. PMID: 28166709; PMCID: PMC5494007

Pickkers P, Ostermann M, Joannidis M, Zarbock A, Hoste E, Bellomo R, Prowle J, Darmon M, Bonventre JV, Forni L, Bagshaw SM, Schetz M. The intensive care medicine agenda on acute kidney injury. Intensive Care Med. 2017 Sep;43(9):1198-1209. doi: 10.1007/s00134-017-4687-2. Epub 2017 Jan 30. PMID: 28138736; PMCID: PMC5534380

Tögel F, Valerius MT, Freedman BS, Iatrino R, Grinstein M, Bonventre JV. Repair after nephron ablation reveals limitations of neonatal neonephrogenesis. JCI Insight. 2017 Jan 26;2(2):e88848. doi: 10.1172/jci.insight.88848. PMID: 28138555; PMCID: PMC5256143

Mendu ML, Ciociolo GR Jr, McLaughlin SR, Graham DA, Ghazinouri R, Parmar S, Grossier A, Rosen R, Laskowski KR, Riella LV, Robinson ES, Charytan DM, Bonventre JV, Greenberg JO, Waikar SS. A Decision-Making Algorithm for Initiation and Discontinuation of RRT in Severe AKI. Clin J Am Soc Nephrol. 2017 Feb 7;12(2):228-236. doi: 10.2215/CJN.07170716. Epub 2017 Jan 24. PMID: 28119408; PMCID: PMC5293339

Niewczas MA, Mathew AV, Croall S, Byun J, Major M, Sabisetti VS, Smiles A, Bonventre JV, Pennathur S, Krolewski AS. Circulating Modified Metabolites and a Risk of ESRD in Patients With Type 1 Diabetes and Chronic Kidney Disease. Diabetes Care. 2017 Mar;40(3):383-390. doi: 10.2337/dc16-0173. Epub 2017 Jan 13. PMID: 28087576; PMCID: PMC5319475

Hsu CY, Xie D, Waikar SS, Bonventre JV, Zhang X, Sabbisetti V, Mifflin TE, Coresh J, Diamantidis CJ, He J, Lora CM, Miller ER, Nelson RG, Ojo AO, Rahman M, Schelling JR, Wilson FP, Kimmel PL, Feldman HI, Vasan RS, Liu KD; CRIC Study Investigators; CKD Biomarkers Consortium. Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression. Kidney Int. 2017 Jan;91(1):196-203. doi: 10.1016/j.kint.2016.09.003. Epub 2016 Oct 28. PMID: 28029431; PMCID: PMC5362331.

Morizane R, Bonventre JV. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells. Nat Protoc. 2017 Jan;12(1):195-207. doi: 10.1038/nprot.2016.170. Epub 2016 Dec 22. PMID: 28005067; PMCID: PMC5278902

2016

Sochol RD, Gupta NR, Bonventre JV. A Role for 3D Printing in Kidney-on-a-Chip Platforms. Curr Transplant Rep. 2016 Mar;3(1):82-92. doi: 10.1007/s40472-016-0085-x. Epub 2016 Jan 20. PMID: 28090431; PMCID: PMC5232415.

Morizane R, Bonventre JV. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells. Nat Protoc. 2017 Jan;12(1):195-207. doi: 10.1038/nprot.2016.170. Epub 2016 Dec 22. PMID: 28005067; PMCID: PMC5278902.

Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A. ADAM17 substrate release in proximal tubule drives kidney fibrosis. JCI Insight. 2016 Aug 18;1(13):e87023. doi: 10.1172/jci.insight.87023. PMID: 27642633; PMCID: PMC5026414

Li L, Bonventre JV. Endothelial Glycocalyx: Not Just a Sugar Coat. Am J Respir Crit Care Med. 2016 Aug 15;194(4):390-3. doi: 10.1164/rccm.201603-0624ED. PMID: 27525457; PMCID: PMC5441087

Graw JA, Mayeur C, Rosales I, Liu Y, Sabbisetti VS, Riley FE, Rechester O, Malhotra R, Warren HS, Colvin RB, Bonventre JV, Bloch DB, Zapol WM. Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells. Circulation. 2016 Sep 27;134(13):945-60. doi: 10.1161/CIRCULATIONAHA.115.019955. Epub 2016 Aug 11. PMID: 27515135; PMCID: PMC5039096

Wu Y, Xu JX, El-Jouni W, Lu T, Li S, Wang Q, Tran M, Yu W, Wu M, Barrera IE, Bonventre JV, Zhou J, Denker BM, Kong T. Gα12 is required for renal cystogenesis induced by Pkd1 inactivation. J Cell Sci. 2016 Oct 1;129(19):3675-3684. doi: 10.1242/jcs.190496. Epub 2016 Aug 5. PMID: 27505895; PMCID: PMC5087651

Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkin DJ, Bonventre JV, Velayutham TS, Evans SM, Rodino KG, VieBrock L, Scanlon KM, Carbonetti NH, Carlyon JA, Miao EA, McBride JW, Kotsyfakis M, Pedra JH. The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. PLoS Pathog. 2016 Aug 2;12(8):e1005803. doi: 10.1371/journal.ppat.1005803. PMID: 27482714; PMCID: PMC4970705

Cárdenas-González M, Osorio-Yáñez C, Gaspar-Ramírez O, Pavković M, Ochoa-Martínez A, López-Ventura D, Medeiros M, Barbier OC, Pérez-Maldonado IN, Sabbisetti VS, Bonventre JV, Vaidya VS. Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1. Environ Res. 2016 Oct;150:653-662. doi: 10.1016/j.envres.2016.06.032. Epub 2016 Jul 15. PMID: 27431456; PMCID: PMC5003729

Waikar SS, Sabbisetti V, Ärnlöv J, Carlsson AC, Coresh J, Feldman HI, Foster MC, Fufaa GD, Helmersson-Karlqvist J, Hsu CY, Kimmel PL, Larsson A, Liu Y, Lind L, Liu KD, Mifflin TE, Nelson RG, Risérus U, Vasan RS, Xie D, Zhang X, Bonventre JV; Chronic Kidney Disease Biomarkers Consortium Investigators. Relationship of proximal tubular injury to chronic kidney disease as assessed by urinary kidney injury molecule-1 in five cohort studies. Nephrol Dial Transplant. 2016. Sep;31(9):1460-70. doi: 10.1093/ndt/gfw203. Epub 2016 Jun 7. PMID: 27270293; PMCID: PMC5009290

2015

Ismail OZ, Zhang X, Bonventre JV, Gunaratnam L. G protein α12 (Gα12) is a negative regulator of kidney injury molecule-1-mediated efferocytosis. Am J Physiol Renal Physiol. 2016 Apr 1;310(7):F607-F620. doi: 10.1152/ajprenal.00169.2015. Epub 2015 Dec 23. PMID: 26697979; PMCID: PMC4971893.

Brooks CR, Bonventre JV. KIM-1/TIM-1 in proximal tubular cell immune response. Oncotarget. 2015 Dec 29;6(42):44059-60. doi: 10.18632/oncotarget.6623. PMID: 26683362; PMCID: PMC4792540

Naini SM, Choukroun GJ, Ryan JR, Hentschel DM, Shah JV, Bonventre JV. Cytosolic phospholipase A2α regulates G1 progression through modulating FOXO1 activity. FASEB J. 2016 Mar;30(3):1155-70. doi: 10.1096/fj.15-278416. Epub 2015 Dec 7. PMID: 26644349; PMCID: PMC4750418

Suzuki T, Yamaguchi H, Kikusato M, Hashizume O, Nagatoishi S, Matsuo A, Sato T, Kudo T, Matsuhashi T, Murayama K, Ohba Y, Watanabe S, Kanno S, Minaki D, Saigusa D, Shinbo H, Mori N, Yuri A, Yokoro M, Mishima E, Shima H, Akiyama Y, Takeuchi Y, Kikuchi K, Toyohara T, Suzuki C, Ichimura T, Anzai J, Kohzuki M, Mano N, Kure S, Yanagisawa T, Tomioka Y, Toyomizu M, Tsumoto K, Nakada K, Bonventre JV, Ito S, Osaka H, Hayashi K, Abe T. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32. doi: 10.1681/ASN.2015060623. Epub 2015 Nov 25. PMID: 26609120; PMCID: PMC4926982

Humphreys BD, Cantaluppi V, Portilla D, Singbartl K, Yang L, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative (ADQI) XIII Work Group. Targeting Endogenous Repair Pathways after AKI. J Am Soc Nephrol. 2016 Apr;27(4):990-8. doi: 10.1681/ASN.2015030286. Epub 2015 Nov 18. PMID: 26582401; PMCID: PMC4814191

Rabb H, Griffin MD, McKay DB, Swaminathan S, Pickkers P, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative Consensus XIII Work Group. Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps. J Am Soc Nephrol. 2016 Feb;27(2):371-9. doi: 10.1681/ASN.2015030261. Epub 2015 Nov 11. PMID: 26561643; PMCID: PMC4731128
Yin W, Naini SM, Chen G, Hentschel DM, Humphreys BD, Bonventre JV. Mammalian Target of Rapamycin Mediates Kidney Injury Molecule 1-Dependent Tubule Injury in a Surrogate Model. J Am Soc Nephrol. 2016 Jul;27(7):1943-57. doi: 10.1681/ASN.2015050500. Epub 2015 Nov 4. PMID: 26538632; PMCID: PMC4926976

Okusa MD, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative XIII Workgroup. Therapeutic Targets of Human AKI: Harmonizing Human and Animal AKI. J Am Soc Nephrol. 2016 Jan;27(1):44-8. doi: 10.1681/ASN.2015030233. Epub2015 Oct 30. PMID: 26519086; PMCID: PMC4696586

Basile DP, Bonventre JV, Mehta R, Nangaku M, Unwin R, Rosner MH, Kellum JA, Ronco C; ADQI XIII Work Group. Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments. J Am Soc Nephrol. 2016 Mar;27(3):687-97. doi: 10.1681/ASN.2015030309. Epub 2015 Oct 30. PMID: 26519085; PMCID: PMC4769207

Matejovic M, Ince C, Chawla LS, Blantz R, Molitoris BA, Rosner MH, Okusa MD, Kellum JA, Ronco C; ADQI XIII Work Group. Renal Hemodynamics in AKI: In Search of New Treatment Targets. J Am Soc Nephrol. 2016 Jan;27(1):49-58. doi: 10.1681/ASN.2015030234. Epub 2015 Oct 28. PMID: 26510884; PMCID: PMC4696587

Kishi S, Campanholle G, Gohil VM, Perocchi F, Brooks CR, Morizane R, Sabbisetti V, Ichimura T, Mootha VK, Bonventre JV. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Jul 29;2(9):1090-101. doi: 10.1016/j.ebiom.2015.07.035. PMID: 26501107; PMCID: PMC4588407.

Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat Commun. 2015 Oct 23;6:8715. doi: 10.1038/ncomms9715. PMID: 26493500; PMCID: PMC4620584

Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Biotechnol. 2015 Nov;33(11):1193-200. doi: 10.1038/nbt.3392. PMID: 26458176; PMCID: PMC4747858.

Shinke H, Masuda S, Togashi Y, Ikemi Y, Ozawa A, Sato T, Kim YH, Mishima M, Ichimura T, Bonventre JV, Matsubara K. Urinary kidney injury molecule-1 and monocyte chemotactic protein-1 are noninvasive biomarkers of cisplatin-induce nephrotoxicity in lung cancer patients. Cancer Chemother Pharmacol. 2015 Nov;76(5):989-96. doi: 10.1007/s00280-015-2880-y. Epub 2015 Sep 25. PMID: 26407820; PMCID: PMC4624288

Foster MC, Coresh J, Bonventre JV, Sabbisetti VS, Waikar SS, Mifflin TE, Nelson RG, Grams M, Feldman HI, Vasan RS, Kimmel PL, Hsu CY, Liu KD; CKD Biomarkers Consortium. Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study. Clin J Am Soc Nephrol. 2015 Nov 6;10(11):1956-63. doi: 10.2215/CJN.02590315. Epub 2015 Sep 8. PMID: 26350438; PMCID: PMC4633784

Movahedi Naini S, Sheridan AM, Force T, Shah JV, Bonventre JV. Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2. Mol Cell Biol. 2015 Nov;35(21):3768-84. doi: 10.1128/MCB.00184-15. Epub 2015 Aug 24. PMID: 26303530; PMCID: PMC4589591

Brooks CR, Yeung MY, Brooks YS, Chen H, Ichimura T, Henderson JM, Bonventre JV. KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation. EMBO J. 2015 Oct 1;34(19):2441-64. doi: 10.15252/embj.201489838. Epub 2015 Aug 17. PMID: 26282792; PMCID: PMC4601664

Zuk A, Bonventre JV. Acute kidney injury: Can remote ischaemic preconditioning prevent AKI? Nat Rev Nephrol. 2015 Sep;11(9):512-3. doi: 10.1038/nrneph.2015.119. Epub 2015 Jul 28. PMID: 26215511; PMCID: PMC4951154

Khan NS, Song CY, Thirunavukkarasu S, Fang XR, Bonventre JV, Malik KU. Cytosolic Phospholipase A2α Is Essential for Renal Dysfunction and End-Organ Damage Associated With Angiotensin II-Induced Hypertension. Am J Hypertens. 2015 Feb;29(2):258-65. doi: 10.1093/ajh/hpv083. Epub 2015 Jun 4. PMID: 26045535; PMCID: PMC4751243

Deml KF, Schildhaus HU, Compérat E, von Teichman A, Storz M, Schraml P, Bonventre JV, Fend F, Fleige B, Nerlich A, Gabbert HE, GaBler N, Grobholz R, Hailemariam S, Hinze R, Knüchel R, Lhermitte B, Nesi G, Rüdiger T, Sauter G, Moch H. Clear cell papillary renal cell carcinoma and renal angiomyoadenomatous tumor: two variants of a morphologic, immunohistochemical, and genetic distinct entity of renal cell carcinoma. Am J Surg Pathol. 2015 Jul;39(7):889-901. doi: 10.1097/PAS.0000000000000456. PMID: 25970683; PMCID: PMC4465996

Antoine DJ, Sabbisetti VS, Francis B, Jorgensen AL, Craig DG, Simpson KJ, Bonventre JV, Park BK, Dear JW. Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury. Hepatology. 2015 Aug;62(2):591-9. doi: 10.1002/hep.27857. Epub 2015 May 29. PMID: 25891479; PMCID: PMC4515147

Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V, Bonventre JV. KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest. 2015 Apr;125(4):1620-36. doi: 10.1172/JCI75417. Epub 2015 Mar 9. PMID: 25751064; PMCID: PMC4396492

Hsu CY, Ballard S, Batlle D, Bonventre JV, Böttinger EP, Feldman HI, Klein JB, Coresh J, Eckfeldt JH, Inker LA, Kimmel PL, Kusek JW, Liu KD, Mauer M, Mifflin TE, Molitch ME, Nelsestuen GL, Rebholz CM, Rovin BH, Sabbisetti VS, Van Eyk JE, Vasan RS, Waikar SS, Whitehead KM, Nelson RG; CKD Biomarkers Consortium. Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium. Clin J Am Soc Nephrol. 2015 May 7;10(5):894-902. doi: 10.2215/CJN.11541114. Epub 2015 Mar 4. PMID: 25739849; PMCID: PMC4422251

Lam AQ, Bonventre JV. Regenerating the nephron with human pluripotent stem cells. Curr Opin Organ Transplant. 2015 Apr;20(2):187-92. doi: 10.1097/MOT.0000000000000177. PMID: 25695593

Khan NS, Song CY, Jennings BL, Estes AM, Fang XR, Bonventre JV, Malik KU. Cytosolic phospholipase A2α is critical for angiotensin II-induced hypertension and associated cardiovascular pathophysiology. Hypertension. 2015 Apr;65(4):784-92. doi: 10.1161/HYPERTENSIONAHA.114.04803. Epub 2015 Feb 9. PMID: 25667212; PMCID: PMC4359078

Ferenbach DA, Bonventre JV. Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD. Nat Rev Nephrol. 2015 May;11(5):264-76. doi: 10.1038/nrneph.2015.3. Epub 2015 Feb 3. PMID: 25643664; PMCID: PMC4412815

Besschetnova TY, Ichimura T, Katebi N, St Croix B, Bonventre JV, Olsen BR. Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 2015 Mar;42:56-73. doi: 10.1016/j.matbio.2014.12.002. Epub 2015 Jan 5. PMID: 25572963; PMCID: PMC4409530

Xu JX, Lu TS, Li S, Wu Y, Ding L, Denker BM, Bonventre JV, Kong T. Polycystin-1 and Gα12 regulate the cleavage of E-cadherin in kidney epithelial cells. Physiol Genomics. 2015 Feb;47(2):24-32. doi: 10.1152/physiolgenomics.00090.2014. Epub 2014 Dec 9. PMID: 25492927; PMCID: PMC4313070

Lagos-Arevalo P, Palijan A, Vertullo L, Devarajan P, Bennett MR, Sabbisetti V, Bonventre JV, Ma Q, Gottesman RD, Zappitelli M. Cystatin C in acute kidney injury diagnosis: early biomarker or alternative to serum creatinine? Pediatr Nephrol. 2015 Apr;30(4):665-76. doi: 10.1007/s00467-014-2987-0. Epub 2014 Dec 5. PMID: 25475610; PMCID: PMC4372053

Pang P, Jin X, Proctor BM, Farley M, Roy N, Chin MS, von Andrian UH, Vollmann E, Perro M, Hoffman RJ, Chung J, Chauhan N, Mistri M, Muslin AJ, Bonventre JV, Siedlecki AM. RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm. Kidney Int. 2015 Apr;87(4):771-83. doi: 10.1038/ki.2014.364. Epub 2014 Dec 3. PMID: 25469849; PMCID: PMC4382433

Fufaa GD, Weil EJ, Nelson RG, Hanson RL, Bonventre JV, Sabbisetti V, Waikar SS, Mifflin TE, Zhang X, Xie D, Hsu CY, Feldman HI, Coresh J, Vasan RS, Kimmel PL, Liu KD; Chronic Kidney Disease Biomarkers Consortium Investigators. Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus. Diabetologia. 2015 Jan;58(1):188-98. doi: 10.1007/s00125-014-3389-3. Epub 2014 Oct 15. PMID: 25316431; PMCID: PMC4258130

Canaud G, Bonventre JV. Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury. Nephrol Dial Transplant. 2015 Apr;30(4):575-83. doi: 10.1093/ndt/gfu230.Epub 2014 Jul 12. PMID: 25016609; PMCID: PMC4370290

Parrinello G, Greene SJ, Torres D, Alderman M, Bonventre JV, Di Pasquale P, Gargani L, Nohria A, Fonarow GC, Vaduganathan M, Butler J, Paterna S, Stevenson LW, Gheorghiade M. Water and sodium in heart failure: a spotlight on congestion. Heart Fail Rev. 2015 Jan;20(1):13-24. doi: 10.1007/s10741-014-9438-7. PMID: 24942806; PMCID: PMC4405162

2014

Bonventre JV. Primary proximal tubule injury leads to epithelial cell cycle arrest, fibrosis, vascular rarefaction, and glomerulosclerosis. Kidney Int Suppl (2011). 2014 Nov;4(1):39-44. doi: 10.1038/kisup.2014.8. PMID: 26310195; PMCID: PMC4536970

Xu JX, Lu TS, Li S, Wu Y, Ding L, Denker BM, Bonventre JV, Kong T. Polycystin-1 and Gα12 regulate the cleavage of E-cadherin in kidney epithelial cells. Physiol Genomics. 2015 Feb;47(2):24-32. doi: 10.1152/physiolgenomics.00090.2014. Epub 2014 Dec 9. PMID: 25492927; PMCID: PMC4313070

Lagos-Arevalo P, Palijan A, Vertullo L, Devarajan P, Bennett MR, Sabbisetti V, Bonventre JV, Ma Q, Gottesman RD, Zappitelli M. Cystatin C in acute kidney injury diagnosis: early biomarker or alternative to serum creatinine? Pediatr Nephrol. 2015 Apr;30(4):665-76. doi: 10.1007/s00467- 014-2987-0. Epub 2014 Dec 5. PMID: 25475610; PMCID: PMC4372053

Pang P, Jin X, Proctor BM, Farley M, Roy N, Chin MS, von Andrian UH, Vollmann E, Perro M, Hoffman RJ, Chung J, Chauhan N, Mistri M, Muslin AJ, Bonventre JV, Siedlecki AM. RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm. Kidney Int. 2015 Apr;87(4):771-83. doi: 10.1038/ki.2014.364. Epub 2014 Dec 3. PMID: 25469849; PMCID: PMC4382433

Bonventre JV. Maladaptive proximal tubule repair: cell cycle arrest. Nephron Clin Pract. 2014;127(1-4):61-4. doi: 10.1159/000363673. Epub 2014 Sep 24. PMID: 25343823

Fufaa GD, Weil EJ, Nelson RG, Hanson RL, Bonventre JV, Sabbisetti V, Waikar SS, Mifflin TE, Zhang X, Xie D, Hsu CY, Feldman HI, Coresh J, Vasan RS, Kimmel PL, Liu KD; Chronic Kidney Disease Biomarkers Consortium Investigators. Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus. Diabetologia. 2015 Jan;58(1):188-98. doi: 10.1007/s00125-014-3389-3. Epub 2014 Oct 15. PMID: 25316431; PMCID: PMC4258130

Wang X, Bonventre JV, Parrish AR. The aging kidney: increased susceptibility to nephrotoxicity. Int J Mol Sci. 2014 Sep 1;15(9):15358-76. doi: 10.3390/ijms150915358. PMID: 25257519; PMCID: PMC4200815

Bonventre JV, Boulware LE, Dember LM, Freedman BI, Furth SL, Holzman LB, Ketchum CJ, Little MH, Mehrotra R, Moe SM, Sands JM, Sedor JR, Somlo S, Star RA, Rys-Sikora KE; Kidney Research National Dialogue (KRND). The kidney research national dialogue: gearing up to move forward. Clin J Am Soc Nephrol. 2014 Oct 7;9(10):1806-11. doi: 10.2215/CJN.07310714. Epub 2014 Sep 15. PMID: 25225184; PMCID: PMC4186514

Lam AQ, Freedman BS, Bonventre JV. Directed differentiation of pluripotent stem cells to kidney cells. Semin Nephrol. 2014 Jul;34(4):445-61. doi: 10.1016/j.semnephrol.2014.06.011. Epub 2014 Jun 13. PMID: 25217273; PMCID: PMC4893322

Bonventre JV. Kidney injury molecule-1: a translational journey. Trans Am Clin Climatol Assoc. 2014;125:293-9; discussion 299. PMID: 25125746; PMCID: PMC4112686

Canaud G, Bonventre JV. Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury. Nephrol Dial Transplant. 2015 Apr;30(4):575-83. doi: 10.1093/ndt/gfu230. Epub 2014 Jul 12. PMID: 25016609; PMCID: PMC4370290.

Sabbisetti VS, Waikar SS, Antoine DJ, Smiles A, Wang C, Ravisankar A, Ito K, Sharma S, Ramadesikan S, Lee M, Briskin R, De Jager PL, Ngo TT, Radlinski M, Dear JW, Park KB, Betensky R, Krolewski AS, Bonventre JV. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J Am Soc Nephrol. 2014 Oct;25(10):2177-86. doi: 10.1681/ASN.2013070758. Epub 2014 Jun 5. PMID: 24904085; PMCID: PMC4178434

Hsiao LL, Wu J, Yeh AC, Shieh EC, Cui C, Li A, Polding LC, Ahmed R, Lim K, Lu TS, Rhee CM, Bonventre JV. The Kidney Disease Screening and Awareness Program (KDSAP): a novel translatable model for increasing interest in nephrology careers. J Am Soc Nephrol. 2014 Sep;25(9):1909-15. doi: 10.1681/ASN.2013090928. Epub 2014 May 29. PMID: 24876120; PMCID: PMC414797

Mishima E, Inoue C, Saigusa D, Inoue R, Ito K, Suzuki Y, Jinno D, Tsukui Y, Akamatsu Y, Araki M, Araki K, Shimizu R, Shinke H, Suzuki T, Takeuchi Y, Shima H, Akiyama Y, Toyohara T, Suzuki C, Saiki Y, Tominaga T, Miyagi S, Kawagisihi N, Soga T, Ohkubo T, Yamamura K, Imai Y, Masuda S, Sabbisetti V, Ichimura T, Mount DB, Bonventre JV, Ito S, Tomioka Y, Itoh K, Abe T. Conformational change in transfer RNA is an early indicator of acute cellular damage. J Am Soc Nephrol. 2014 Oct;25(10):2316-26. doi: 10.1681/ASN.2013091001. Epub 2014 May 15. PMID: 24833129; PMCID: PMC4178440

Gandhi R, Yi J, Ha J, Shi H, Ismail O, Nathoo S, Bonventre JV, Zhang X, Gunaratnam L. Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis. Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F205-21. doi: 10.1152/ajprenal.00638.2013. Epub 2014 May 14. PMID: 24829508; PMCID: PMC4380482

Ronco C, Bonventre JV. Stigmata of death: for kidneys and patients. Nephrol Dial Transplant. 2014 Oct;29(10):1797-8. doi: 10.1093/ndt/gfu103. Epub 2014 May 2. PMID: 24792373; PMCID: PMC4838006

Bassi R, Vergani A, D’Addio F, Ben Nasr M, Mocci A, Rastaldi MP, Ichimura T, Bonventre JV, Fiorina P. Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report. Springerplus. 2014 Mar 24;3:158. doi: 10.1186/2193-1801-3-158. PMID: 24741476; PMCID: PMC3979974

McWilliam SJ, Antoine DJ, Sabbisetti V, Pearce RE, Jorgensen AL, Lin Y, Leeder JS, Bonventre JV, Smyth RL, Pirmohamed M. Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children. Biomark Med. 2014;8(10):1189-97. doi: 10.2217/bmm.14.36. PMID: 24661102; PMCID: PMC4076175

Liu NK, Deng LX, Zhang YP, Lu QB, Wang XF, Hu JG, Oakes E, Bonventre JV, Shields CB, Xu XM. Cytosolic phospholipase A2 protein as a novel therapeutic target for spinal cord injury. Ann Neurol. 2014 May;75(5):644-58. doi: 10.1002/ana.24134. Epub 2014 Apr 2. PMID: 24623140; PMCID: PMC4320750

Niewczas MA, Sirich TL, Mathew AV, Skupien J, Mohney RP, Warram JH, Smiles A, Huang X, Walker W, Byun J, Karoly ED, Kensicki EM, Berry GT, Bonventre JV, Pennathur S, Meyer TW, Krolewski AS. Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study. Kidney Int. 2014 May;85(5):1214-24. doi: 10.1038/ki.2013.497. Epub 2014 Jan 15. PMID: 24429397; PMCID: PMC4072128

Lam AQ, Freedman BS, Morizane R, Lerou PH, Valerius MT, Bonventre JV. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol. 2014 Jun;25(6):1211-25. doi: 10.1681/ASN.2013080831. Epub 2013 Dec 19. PMID: 24357672; PMCID: PMC4033376

Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J Biol Chem. 2014 Jan 17;289(3):1491-504. doi: 10.1074/jbc.M113.497651. Epub 2013 Dec 2. PMID: 24297180; PMCID: PMC3894331

Zhang PL, Mashni JW, Sabbisetti VS, Schworer CM, Wilson GD, Wolforth SC, Kernen KM, Seifman BD, Amin MB, Geddes TJ, Lin F, Bonventre JV, Hafron JM. Urine kidney injury molecule-1: a potential non-invasive biomarker for patients with renal cell carcinoma. Int Urol Nephrol. 2014 Feb;46(2):379-88. doi: 10.1007/s11255-013-0522-z. Epub 2013 Aug 25. PMID: 23979814; PMCID: PMC4066455

2013

Fahmy N, Sener A, Sabbisetti V, Nott L, Lang RM, Welk BK, Méndez-Probst CE, MacPhee RA, VanEerdewijk S, Cadieux PA, Bonventre JV, Razvi H. Urinary expression of novel tissue markers of kidney injury after ureteroscopy, shockwave lithotripsy, and in normal healthy controls. J Endourol. 2013 Dec;27(12):1455-62. doi: 10.1089/end.2013.0188. Epub 2013 Nov 1. PMID: 24180435; PMCID: PMC3997088.

Bonventre JV. Antifibrotic vitamin D analogs. J Clin Invest. 2013 Nov;123(11):4570-3. doi: 10.1172/JCI72748. Epub 2013 Oct 25. PMID: 24162671; PMCID: PMC3809811

Freedman BS, Lam AQ, Sundsbak JL, Iatrino R, Su X, Koon SJ, Wu M, Daheron L, Harris PC, Zhou J, Bonventre JV. Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations. J Am Soc Nephrol. 2013 Oct;24(10):1571-86. doi: 10.1681/ASN.2012111089. Epub 2013 Sep 5. PMID: 24009235; PMCID: PMC3785271

Waikar SS, Betensky RA, Emerson SC, Bonventre JV. Imperfect gold standards for biomarker evaluation. Clin Trials. 2013 Oct;10(5):696-700. doi: 10.1177/1740774513497540. Epub 2013 Sep 3. PMID: 24006246; PMCID: PMC3800226

Zhang PL, Mashni JW, Sabbisetti VS, Schworer CM, Wilson GD, Wolforth SC, Kernen KM, Seifman BD, Amin MB, Geddes TJ, Lin F, Bonventre JV, Hafron JM. Urine kidney injury molecule-1: a potential non-invasive biomarker for patients with renal cell carcinoma. Int Urol Nephrol. 2014 Feb;46(2):379-88. doi: 10.1007/s11255-013-0522-z. Epub 2013 Aug 25. PMID: 23979814; PMCID: PMC4066455

Humphreys BD, Xu F, Sabbisetti V, Grgic I, Movahedi Naini S, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV. Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest. 2013 Sep;123(9):4023-35. doi: 10.1172/JCI45361. Epub 2013 Aug 27. PMID: 23979159; PMCID: PMC3755983

Suram S, Silveira LJ, Mahaffey S, Brown GD, Bonventre JV, Williams DL, Gow NA, Bratton DL, Murphy RC, Leslie CC. Cytosolic phospholipase A(2)α and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. PLoS One. 2013 Jul 25;8(7):e69002. doi: 10.1371/journal.pone.0069002. PMID: 23950842; PMCID: PMC3742295

Bonventre JV, Basile D, Liu KD, McKay D, Molitoris BA, Nath KA, Nickolas TL, Okusa MD, Palevsky PM, Schnellmann R, Rys-Sikora K, Kimmel PL, Star RA; Kidney Research National Dialogue (KRND). AKI: a path forward. Clin J Am Soc Nephrol. 2013 Sep;8(9):1606-8. doi: 10.2215/CJN.06040613. Epub 2013 Jul 18. PMID: 23868899; PMCID: PMC3805072

Susantitaphong P, Perianayagam MC, Tighiouart H, Liangos O, Bonventre JV, Jaber BL. Tumor necrosis factor alpha promoter polymorphism and severity of acute kidney injury. Nephron Clin Pract. 2013;123(1-2):67-73. doi: 10.1159/000351684. Epub 2013 Jun 21. PMID: 23796916; PMCID: PMC4959276

Tögel FE, Bonventre JV. Multipotent mesenchymal stromal cells protect against kidney injury. Cytotherapy. 2013 Jun;15(6):629-31. doi: 10.1016/j.jcyt.2013.04.005. PMID: 23643304; PMCID: PMC4077161

Timsit MO, Adams WJ, Laguna-Fernandez A, Ichimura T, Bonventre JV, García-Cardeña G, Tullius SG. Flow is critical for maintaining a protective phenotype in renal proximal tubular cells. Am J Transplant. 2013 Jun;13(6):1617-8. doi: 10.1111/ajt.12242. Epub 2013 Apr 25. PMID: 23617882; PMCID: PMC4625983

Greenberg JO, Vakharia N, Szent-Gyorgyi LE, Desai SP, Turchin A, Forman J, Bonventre JV, Kachalia A. Meaningful measurement: developing a measurement system to improve blood pressure control in patients with chronic kidney disease. J Am Med Inform Assoc. 2013 Jun;20(e1):e97-e101. doi: 10.1136/amiajnl-2012-001308. Epub 2013 Jan 23. PMID: 23345408; PMCID: PMC3715343

Nishihara K, Masuda S, Shinke H, Ozawa A, Ichimura T, Yonezawa A, Nakagawa S, Inui K, Bonventre JV, Matsubara K. Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection. of cisplatin-induced nephrotoxicity. Biochem Pharmacol. 2013 Feb 15;85(4):570-82. doi: 10.1016/j.bcp.2012.12.019. Epub 2013 Jan 2. PMID: 23291264; PMCID: PMC4077184

Salahudeen AK, Bonventre JV. Onconephrology: the latest frontier in the war against kidney disease. J Am Soc Nephrol. 2013 Jan;24(1):26-30. doi: 10.1681/ASN.2012070690. Epub 2012 Nov 8. PMID: 23138480

Sabbisetti VS, Ito K, Wang C, Yang L, Mefferd SC, Bonventre JV. Novel assays for detection of urinary KIM-1 in mouse models of kidney injury. Toxicol Sci. 2013 Jan;131(1):13-25. doi: 10.1093/toxsci/kfs268. Epub 2012 Sep 27. PMID: 23019274; PMCID: PMC3621351.

2012

Milwid JM, Ichimura T, Li M, Jiao Y, Lee J, Yarmush JS, Parekkadan B, Tilles AW, Bonventre JV, Yarmush ML. Secreted factors from bone marrow stromal cells upregulate IL-10 and reverse acute kidney injury. Stem Cells Int. 2012;2012:392050. doi: 10.1155/2012/392050. Epub 2012Dec 19. PMID: 23319959; PMCID: PMC3539665

Bonventre JV. Can we target tubular damage to prevent renal function decline in diabetes? Semin Nephrol. 2012 Sep;32(5):452-62. doi: 10.1016/j.semnephrol.2012.07.008. PMID: 23062986; PMCID: PMC3595316

Krolewski AS, Bonventre JV. High risk of ESRD in type 1 diabetes: new strategies are needed to retard progressive renal function decline. Semin Nephrol. 2012 Sep;32(5):407-14. doi: 10.1016/j.semnephrol.2012.07.002. PMID: 23062980; PMCID: PMC3474985

Krolewski AS, Bonventre JV. High risk of ESRD in type 1 diabetes: call for action: introduction. Semin Nephrol. 2012 Sep;32(5):405-6. doi: 10.1016/j.semnephrol.2012.07.001. PMID: 23062979

Sabbisetti VS, Ito K, Wang C, Yang L, Mefferd SC, Bonventre JV. Novel assays for detection of urinary KIM-1 in mouse models of kidney injury. Toxicol Sci. 2013 Jan;131(1):13-25. doi: 10.1093/toxsci/kfs268. Epub 2012 Sep 27. PMID: 23019274; PMCID: PMC3621351

McWilliam SJ, Antoine DJ, Sabbisetti V, Turner MA, Farragher T, Bonventre JV, Park BK, Smyth RL, Pirmohamed M. Mechanism-based urinary biomarkers to identify the potential for aminoglycoside-induced nephrotoxicity in premature neonates: a proof-of-concept study. PLoS One. 2012;7(8):e43809. doi: 10.1371/journal.pone.0043809. Epub 2012 Aug 24. PMID: 22937100; PMCID: PMC3427159

Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12105-10. doi: 10.1073/pnas.1120914109. Epub 2012 Jul 5. PMID: 22773818; PMCID: PMC3409739

Peralta CA, Katz R, Bonventre JV, Sabbisetti V, Siscovick D, Sarnak M, Shlipak MG. Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis. 2012 Dec;60(6):904-11. doi: 10.1053/j.ajkd.2012.05.014. Epub 2012 Jun 30. PMID: 22749388; PMCID: PMC3690926

Bonventre JV. Limb ischemia protects against contrast-induced nephropathy. Circulation. 2012 Jul 24;126(4):384-7. doi: 10.1161/CIRCULATIONAHA.112.119701. Epub 2012 Jun 26. PMID: 22735307; PMCID: PMC3574167

Sengupta P, Basu S, Soni S, Pandey A, Roy B, Oh MS, Chin KT, Paraskar AS, Sarangi S, Connor Y, Sabbisetti VS, Kopparam J, Kulkarni A, Muto K, Amarasiriwardena C, Jayawardene I, Lupoli N, Dinulescu DM, Bonventre JV, Mashelkar RA, Sengupta S. Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11294-9. doi: 10.1073/pnas.1203129109. Epub 2012 Jun 25. PMID: 22733767; PMCID: PMC3396529

Kurusu S, Sapirstein A, Bonventre JV. Group IVA phospholipase A₂ optimizes ovulation and fertilization in rodents through induction of and metabolic coupling with prostaglandin endoperoxide synthase 2. FASEB J. 2012 Sep;26(9):3800-10. doi: 10.1096/fj.12-203968. Epub 2012 Jun 6. PMID: 22673578; PMCID: PMC3425826

Vermeulen R, Zhang L, Spierenburg A, Tang X, Bonventre JV, Reiss B, Shen M, Smith MT, Qiu C, Ge Y, Ji Z, Xiong J, He J, Hao Z, Liu S, Xie Y, Yue F, Guo W, Purdue M, Beane Freeman LE, Sabbisetti V, Li L, Huang H, Rothman N, Lan Q. Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene. Carcinogenesis. 2012 Aug;33(8):1538-41. doi: 10.1093/carcin/bgs191. Epub 2012 Jun 4. PMID: 22665366; PMCID: PMC3499056

Mizuguchi KA, Mitani A, Waikar SS, Ireland P, Panizales C, Deluke G, Sugarbaker DJ, Bonventre JV, Frendl G. Use of postoperative creatinine to predict sustained kidney injury in patients undergoing mesothelioma surgery. Clin J Am Soc Nephrol. 2012 Jul;7(7):1071-8. doi: 10.2215/CJN.12401211. Epub: 2012 Apr 26. PMID: 22537654; PMCID: PMC3386676

Ichimura T, Brooks CR, Bonventre JV. Kim-1/Tim-1 and immune cells: shifting sands. Kidney Int. 2012 May;81(9):809-11. doi: 10.1038/ki.2012.11. PMID: 22499138; PMCID: PMC3339439

Sangoi AR, McKenney JK, Brooks JD, Bonventre JV, Higgins JP. Evaluation of putative renal cell carcinoma markers PAX-2, PAX-8, and hKIM-1 in germ cell tumors: a tissue microarray study of 100 cases. Appl Immunohistochem Mol Morphol. 2012 Oct;20(5):451-3. doi: 10.1097/PAI.0b013e31824bb404. PMID: 22495365; PMCID: PMC4077160

Grgic I, Campanholle G, Bijol V, Wang C, Sabbisetti VS, Ichimura T, Humphreys BD, Bonventre JV. Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis. Kidney Int. 2012 Jul;82(2):172-83. doi: 10.1038/ki.2012.20. Epub 2012 Mar 21. PMID: 22437410; PMCID: PMC3480325

Nejat M, Pickering JW, Devarajan P, Bonventre JV, Edelstein CL, Walker RJ, Endre ZH. Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney Int. 2012 Jun;81(12):1254-62. doi: 10.1038/ki.2012.23. Epub 2012 Mar 14. PMID: 22418979; PMCID: PMC3365288

Grgic I, Brooks CR, Hofmeister AF, Bijol V, Bonventre JV, Humphreys BD. Imaging of podocyte foot processes by fluorescence microscopy. J Am Soc Nephrol.2012 May;23(5):785-91. doi: 10.1681/ASN.2011100988. Epub 2012 Feb 23. PMID: 22362911; PMCID: PMC3338299

Roy-Chaudhury P, Yevzlin A, Bonventre JV, Agarwal A, Almehmi A, Besarab A, Dwyer A, Hentschel DM, Kraus M, Maya I, Pflederer T, Schon D, Wu S, Work J. Academic interventional nephrology: a model for training, research, and patient care. Clin J Am Soc Nephrol. 2012 Mar;7(3):521-4. doi: 10.2215/CJN.08360811. Epub 2012 Feb 16. PMID: 22344507

Gardiner L, Akintola A, Chen G, Catania JM, Vaidya V, Burghardt RC, Bonventre JV, Trzeciakowski J, Parrish AR. Structural equation modeling highlights the potential of Kim-1 as a biomarker for chronic kidney disease. Am J Nephrol. 2012;35(2):152-63. doi: 10.1159/000335579. Epub 2012 Jan 20. PMID: 22269876; PMCID: PMC3326283

Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y, Si H, Cai H, Bonventre JV, Shen J. Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener. 2012 Jan 9;7:2. doi: 10.1186/1750-1326-7-2. PMID: 22230652; PMCID: PMC3296570

Ralib AM, Pickering JW, Shaw GM, Devarajan P, Edelstein CL, Bonventre JV, Endre ZH. Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J Am Soc Nephrol. 2012 Feb;23(2):322-33. doi: 10.1681/ASN.2011040325. Epub 2011 Nov 17. PMID: 22095948; PMCID: PMC3269182

Waikar SS, Betensky RA, Emerson SC, Bonventre JV. Imperfect gold standards for kidney injury biomarker evaluation. J Am Soc Nephrol. 2012 Jan;23(1):13-21. doi: 10.1681/ASN.2010111124. Epub 2011 Oct 21. PMID: 22021710; PMCID: PMC3695762

2011

Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 2011 Nov;121(11):4210-21. doi: 10.1172/JCI45161. Epub 2011 Nov 1. PMID: 22045571; PMCID: PMC3204829

Qin Y, Alderliesten MC, Stokman G, Pennekamp P, Bonventre JV, de Heer E, Ichimura T, de Graauw M, Price LS, van de Water B. Focal adhesion kinase signaling mediates acute renal injury induced by ischemia/reperfusion. Am J Pathol. 2011 Dec;179(6):2766-78. doi: 10.1016/j.ajpath.2011.08.025. Epub 2011 Oct 5. PMID: 21982831; PMCID: PMC3260828

Yang L, Humphreys BD, Bonventre JV. Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. Contrib Nephrol. 2011;174:149-155. doi: 10.1159/000329385. Epub 2011 Sep 9. PMID: 21921619

Kerkelä R, Boucher M, Zaka R, Gao E, Harris D, Piuhola J, Song J, Serpi R, Woulfe KC, Cheung JY, O’Leary E, Bonventre JV, Force T. Cytosolic phospholipase A(2)α protects against ischemia/reperfusion injury in the heart. Clin Transl Sci. 2011 Aug;4(4):236-42. doi: 10.1111/j.1752-8062.2011.00294.x. PMID: 21884509; PMCID: PMC3170125

Jeong EM, Ahn KH, Jeon HJ, Kim HD, Lee HS, Jung SY, Jung KM, Kim SK, Bonventre JV, Kim DK. Purification and characterization of a cytosolic Ca(2+)-independent phospholipase A(2) from bovine brain. Mol Cells. 2011 Nov;32(5):405-13. doi: 10.1007/s10059-011-1058-7. Epub 2011 Aug 25. PMID: 21874539; PMCID: PMC3887695

Kurusu S, Sapirstein A, Sawada H, Kawaminami M, Bonventre JV. Group IVA phospholipase A2 regulates testosterone biosynthesis by murine Leydig cells and is required for timely sexual maturation. Biochem J. 2011 Nov 1;439(3):403-11. doi: 10.1042/BJ20102167. PMID: 21762109; PMCID: PMC4372093

Humphreys BD, Czerniak S, DiRocco DP, Hasnain W, Cheema R, Bonventre JV. Repair of injured proximal tubule does not involve specialized progenitors. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9226-31. doi: 10.1073/pnas.1100629108. Epub 2011 May 16. PMID: 21576461; PMCID: PMC3107336

Sangoi AR, Fujiwara M, West RB, Montgomery KD, Bonventre JV, Higgins JP, Rouse RV, Gokden N, McKenney JK. Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal cell carcinoma: a study of 248 cases. Am J Surg Pathol. 2011 May;35(5):678-86. doi: 10.1097/PAS.0b013e3182152629. PMID: 21490444; PMCID: PMC4124747

Endre ZH, Pickering JW, Walker RJ, Devarajan P, Edelstein CL, Bonventre JV, Frampton CM, Bennett MR, Ma Q, Sabbisetti VS, Vaidya VS, Walcher AM, Shaw GM, Henderson SJ, Nejat M, Schollum JB, George PM. Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int. 2011 May;79(10):1119-30. doi: 10.1038/ki.2010.555. Epub 2011 Feb 9. PMID: 21307838; PMCID: PMC3884688

Frasch SC, Fernandez-Boyanapalli RF, Berry KZ, Leslie CC, Bonventre JV, Murphy RC, Henson PM, Bratton DL. Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity. J Biol Chem. 2011 Apr 8;286(14):12108-22. doi: 10.1074/jbc.M110.181800. Epub 2011 Feb 4. PMID: 21297111; PMCID: PMC3069415

Lee HJ, Park J, Yoon OJ, Kim HW, Lee DY, Kim DH, Lee WB, Lee NE, Bonventre JV, Kim SS. Amine modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model. Nat Nanotechnol. 2011 Feb;6(2):121-125. doi: 10.1038/nnano.2010.281. Epub 2011 Jan 30. PMID: 21278749; PMCID: PMC4113082

Ly JP, Onay T, Sison K, Sivaskandarajah G, Sabbisetti V, Li L, Bonventre JV, Flenniken A, Paragas N, Barasch JM, Adamson SL, Osborne L, Rossant J, Schnermann J, Quaggin SE. The Sweet Pee model for Sglt2 mutation. J Am Soc Nephrol. 2011 Jan;22(1):113-23. doi: 10.1681/ASN.2010080888. PMID: 21209254; PMCID: PMC3014040

Vaidya VS, Niewczas MA, Ficociello LH, Johnson AC, Collings FB, Warram JH, Krolewski AS, Bonventre JV. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D glucosaminidase. Kidney Int. 2011 Feb;79(4):464-70. doi: 10.1038/ki.2010.404. Epub 2010 Oct 27. PMID: 20980978; PMCID: PMC3033751

2010

Vaidya VS, Niewczas MA, Ficociello LH, Johnson AC, Collings FB, Warram JH, Krolewski AS, Bonventre JV. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase. Kidney Int. 2011 Feb;79(4):464-70. doi: 10.1038/ki.2010.404. Epub 2010 Oct 27. PMID: 20980978; PMCID: PMC3033751

Bonventre JV, Yang L. Kidney injury molecule-1. Curr Opin Crit Care. 2010 Dec;16(6):556-61. doi: 10.1097/MCC.0b013e32834008d3. PMID: 20930626

Koyner JL, Vaidya VS, Bennett MR, Ma Q, Worcester E, Akhter SA, Raman J, Jeevanandam V, O’Connor MF, Devarajan P, Bonventre JV, Murray PT. Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol. 2010 Dec;5(12):2154-65. doi: 10.2215/CJN.00740110. Epub 2010 Aug 26. PMID: 20798258; PMCID: PMC2994075

Li B, Castano AP, Hudson TE, Nowlin BT, Lin SL, Bonventre JV, Swanson KD, Duffield JS. The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair. FASEB J. 2010 Dec;24(12):4767-81. doi: 10.1096/fj.10-154757. Epub 2010 Aug 13. PMID: 20709912; PMCID: PMC2992370

Krishnamoorthy A, Clement ME, O’Leary E, Bonventre JV, Vaidya VS. TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity. Toxicol Sci. 2010 Nov;118(1):298-306. doi: 10.1093/toxsci/kfq240. Epub 2010 Aug 11. PMID: 20702592; PMCID: PMC2955214

Damman K, Van Veldhuisen DJ, Navis G, Vaidya VS, Smilde TD, Westenbrink BD, Bonventre JV, Voors AA, Hillege HL. Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate. Heart. 2010 Aug;96(16):1297-302. doi: 10.1136/hrt.2010.194878. PMID: 20659949; PMCID: PMC3480323

Suram S, Gangelhoff TA, Taylor PR, Rosas M, Brown GD, Bonventre JV, Akira S, Uematsu S, Williams DL, Murphy RC, Leslie CC. Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans. J Biol Chem. 2010 Oct 1;285(40):30676-85. doi: 10.1074/jbc.M110.143800. Epub 2010 Jul 18. PMID: 20643646; PMCID: PMC2945562

Waikar SS, Sabbisetti VS, Bonventre JV. Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int. 2010 Sep;78(5):486-94. doi: 10.1038/ki.2010.165. Epub 2010 Jun 16. PMID: 20555318; PMCID: PMC3025699

Vaidya VS, Ozer JS, Dieterle F, Collings FB, Ramirez V, Troth S, Muniappa N, Thudium D, Gerhold D, Holder DJ, Bobadilla NA, Marrer E, Perentes E, Cordier A, Vonderscher J, Maurer G, Goerin PL, Sistare FD, Bonventre JV. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol. 2010 May;28(5):478-85. doi: 10.1038/nbt.1623. PMID: 20458318; PMCID: PMC2885849

Thudium D, Gerhold D, Holder DJ, Bobadilla NA, Marrer E, Perentes E, Cordier A, Vonderscher J, Maurer G, Goering PL, Sistare FD, Bonventre JV. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol. 2010 May;28(5):478-85. doi: 10.1038/nbt.1623. PMID: 20458318; PMCID: PMC2885849

Bonventre JV, Vaidya VS, Schmouder R, Feig P, Dieterle F. Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol. 2010 May;28(5):436-40. doi: 10.1038/nbt0510-436. PMID: 20458311; PMCID: PMC3033582

Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med. 2010 May;16(5):535-43, 1p following 143. doi: 10.1038/nm.2144. Epub 2010 May 2. PMID: 20436483; PMCID: PMC3928013

Bonventre JV. Pathophysiology of AKI: injury and normal and abnormal repair. Contrib Nephrol. 2010;165:9-17. doi: 10.1159/000313738. Epub 2010 Apr 20. PMID: 20427950

Kim J, Kim DS, Park MJ, Cho HJ, Zervos AS, Bonventre JV, Park KM. Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2010 Jun;298(6):F1332-40. doi: 10.1152/ajprenal.00737.2009. Epub 2010 Mar 10. PMID: 20219823; PMCID: PMC2886814

Hoffmann D, Adler M, Vaidya VS, Rached E, Mulrane L, Gallagher WM, Callanan JJ, Gautier JC, Matheis K, Staedtler F, Dieterle F, Brandenburg A, Sposny A, Hewitt P, Ellinger-Ziegelbauer H, Bonventre JV, Dekant W, Mally A. Performance of novel kidney biomarkers in preclinical toxicity studies. Toxicol Sci. 2010 Jul;116(1):8-22. doi: 10.1093/toxsci/kfq029. Epub 2010 Jan 29. PMID: 20118187; PMCID: PMC2886853

Nishihara K, Masuda S, Nakagawa S, Yonezawa A, Ichimura T, Bonventre JV, Inui K. Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats. Am J Physiol Renal Physiol. 2010 Apr;298(4):F923-34. doi: 10.1152/ajprenal.00567.2009. Epub 2010 Jan 13. PMID: 20071461; PMCID: PMC4380486

Schröppel B, Krüger B, Walsh L, Yeung M, Harris S, Garrison K, Himmelfarb J, Lerner SM, Bromberg JS, Zhang PL, Bonventre JV, Wang Z, Farris AB, Colvin RB, Murphy BT, Vella JP. Tubular expression of KIM-1 does not predict delayed function after transplantation. J Am Soc Nephrol. 2010 Mar;21(3):536-42. doi: 10.1681/ASN.2009040390. Epub 2009 Dec 17. PMID: 20019169; PMCID: PMC2831861

Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol. 2010 Jan;176(1):85-97. doi: 10.2353/ajpath.2010.090517. Epub 2009 Dec 11. PMID: 20008127; PMCID: PMC2797872

Ferguson MA, Vaidya VS, Waikar SS, Collings FB, Sunderland KE, Gioules CJ, Bonventre JV. Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury. Kidney Int. 2010 Apr;77(8):708-14. doi: 10.1038/ki.2009.422. Epub 2009 Nov 25. PMID: 19940842; PMCID: PMC2880954

Espandiari P, Rosenzweig B, Zhang J, Zhou Y, Schnackenberg L, Vaidya VS, Goering PL, Brown RP, Bonventre JV, Mahjoob K, Holland RD, Beger RD, Thompson K, Hanig J, Sadrieh N. Age-related differences in susceptibility to cisplatin-induced renal toxicity. J Appl Toxicol. 2010 Mar;30(2):172-82. doi: 10.1002/jat.1484. PMID: 19839026; PMCID: PMC2829343

Parti RP, Loper R, Brown GD, Gordon S, Taylor PR, Bonventre JV, Murphy RC, Williams DL, Leslie CC. Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1. Am J Respir Cell Mol Biol. 2010 Apr;42(4):415-23. doi: 10.1165/rcmb.2009-0110OC. Epub 2009 Jun 5. PMID: 19502385; PMCI