{"id":396,"date":"2016-07-20T16:29:30","date_gmt":"2016-07-20T16:29:30","guid":{"rendered":"http:\/\/demo.hashthemes.com\/total\/?page_id=7"},"modified":"2021-05-07T22:32:52","modified_gmt":"2021-05-07T22:32:52","slug":"home","status":"publish","type":"page","link":"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"396\" class=\"elementor elementor-396\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4d3c257 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4d3c257\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7f8bfce\" data-id=\"7f8bfce\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b2daf42 elementor-widget elementor-widget-heading\" data-id=\"b2daf42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">THE LAB<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f9e92d1 elementor-widget elementor-widget-image\" data-id=\"f9e92d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"512\" src=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/2020\/07\/labphoto10-19-768x512.jpg\" class=\"attachment-medium_large size-medium_large wp-image-2146\" alt=\"\" srcset=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/2020\/07\/labphoto10-19-768x512.jpg 768w, https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/2020\/07\/labphoto10-19-300x200.jpg 300w, https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/2020\/07\/labphoto10-19-1024x683.jpg 1024w, https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/2020\/07\/labphoto10-19-350x233.jpg 350w, https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/2020\/07\/labphoto10-19.jpg 1200w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-63e7c4e elementor-widget elementor-widget-text-editor\" data-id=\"63e7c4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The Bonventre Lab is dedicated to rigorous, interdisciplinary research to create innovative technologies and treatments in the fight against kidney \u00a0disease, \u00a0and to uncovering the mechanisms and \u00a0pathologies \u00a0involved in kidney injury and repair. \u00a0Led by Joseph V Bonventre, MD, PhD, a world leader in nephrology for over 40 years, the lab fosters an environment of inquiry, integrity and growth. \u00a0The lab has continuously inspired and supported researchers at all levels, and has produced numerous academic and clinical leaders who shape the study and treatment of kidney disease worldwide.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a35997d elementor-widget elementor-widget-button\" data-id=\"a35997d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/people-2\/current-lab-members-2\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-arrow-alt-circle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Meet the Lab <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89fcc51 elementor-widget elementor-widget-button\" data-id=\"89fcc51\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-arrow-alt-circle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Lab Alumni<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-be22391 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"be22391\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ac3c737\" data-id=\"ac3c737\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1172efc elementor-widget elementor-widget-heading\" data-id=\"1172efc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">DR. BONVENTRE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d9e450d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d9e450d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-36a9b5e\" data-id=\"36a9b5e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0968e85 elementor-widget elementor-widget-image\" data-id=\"0968e85\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/elementor\/thumbs\/jvb2-ot7c7hc691w6irhwdyghpd7wj0y5oxtl42cq8zi16k.png\" title=\"jvb2\" alt=\"Joseph V Bonventre,  MD, PhD\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-13033ff\" data-id=\"13033ff\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f1f5c37 elementor-widget elementor-widget-text-editor\" data-id=\"f1f5c37\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dr. Joseph Bonventre is one of the most influential physician scientists of his generation.<\/p><p>He is Chief of the Division of Renal Medicine and Founding Chief of the Engineering in Medicine Division at Brigham and Women\u2019s Hospital, Past-President of the American Society of Nephrology. He led the Kidney Health Initiative Roadmap Initiative for innovative approaches to kidney replacement therapy. He has trained over 150 individuals in his laboratory, many of whom have assumed leadership positions in science and academic medicine. For five years he was Associate Director and for 10 years the Harvard Director of the Harvard-MIT Division of Health Sciences and Technology, where he was responsible for the MD, MD-PhD or PhD training of more than 500 individuals.\u00a0 He was named one of the three top mentors in the U.S. by postdoctoral fellows in the journal <em>Science <\/em>in 2004. His laboratory generated a protocol for direct differentiation of kidney organoids from human stem cells that is widely used. His lab has a great deal of experience with various animal models of AKI and chronic kidney disease and discovered KIM-1, a widely used biomarker of kidney injury. The lab also identified cell cycle arrest and the subsequent senescence response of the cell as a key mediator of the transition of acute injury to chronic fibrotic kidney disease. The lab&#8217;s work has been cited more than 69,000 times (&gt;26,800 since 2015) and Dr. Bonventre has a citation h-index of 133. He was identified as the most \u00a0cited investigator in the field of acute kidney injury and is #4 on the list of\u00a0 world&#8217;s top 2% of scientists by Stanford University in the area of Urology and Nephrology.<\/p><p>See Dr. Bonventre&#8217;s full profile <a href=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/current_lab_members\/joseph-v-bonventre-md-phd\/\">here<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-231c18b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"231c18b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-3213c3d\" data-id=\"3213c3d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1dcf8e1 elementor-widget elementor-widget-heading\" data-id=\"1dcf8e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">RESEARCH<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-032f3a0 elementor-widget elementor-widget-image\" data-id=\"032f3a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"350\" height=\"350\" src=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/2021\/03\/Untitled-design.png\" class=\"elementor-animation-skew attachment-full size-full wp-image-3722\" alt=\"\" srcset=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/2021\/03\/Untitled-design.png 350w, https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/2021\/03\/Untitled-design-300x300.png 300w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-687d1fc elementor-widget elementor-widget-heading\" data-id=\"687d1fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/research\/kidney-tubular-injury-and-chronic-fibrosis\/\" target=\"_blank\">\nKidney Tubular Injury and Chronic Fibrosis\n<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52ac293 elementor-widget elementor-widget-heading\" data-id=\"52ac293\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Adaptive and Maladaptive Repair after Kidney Injury<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b4785f elementor-widget elementor-widget-text-editor\" data-id=\"7b4785f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A major focus of the laboratory has been the study of the pathophysiology of acute renal failure and processes involved with repair. There are many parallels between repair and the normal development of the kidney. While repair is generally considered to be adaptive it can be maladaptive, especially when the acute injury is superimposed on chronic kidney disease.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-535b02d elementor-widget elementor-widget-button\" data-id=\"535b02d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/research\/kidney-tubular-injury-and-chronic-fibrosis\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-arrow-alt-circle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-e78fd3e\" data-id=\"e78fd3e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27b1cdc elementor-widget elementor-widget-spacer\" data-id=\"27b1cdc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6909ae6 elementor-widget elementor-widget-image\" data-id=\"6909ae6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/elementor\/thumbs\/F5-p42kp2xhoq7b6isk0bkedjvw9cffdq1sevg0c8tdj6.png\" title=\"F5\" alt=\"F5\" class=\"elementor-animation-skew\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97e111 elementor-widget elementor-widget-heading\" data-id=\"e97e111\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/research\/kidney-stem-cells\/\">Kidney Stem Cells<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b404772 elementor-widget elementor-widget-text-editor\" data-id=\"b404772\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The kidney possesses the intrinsic capacity for repair after injury but whether adult kidney stem cells are responsible for epithelial regeneration is unresolved. During nephrogenesis, renal epithelia develop from precursors located in the metanephric mesenchyme that condense to form the nephron.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51d2238 elementor-widget elementor-widget-button\" data-id=\"51d2238\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/research\/kidney-stem-cells\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-arrow-alt-circle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-650c096\" data-id=\"650c096\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-59e6962 elementor-widget elementor-widget-spacer\" data-id=\"59e6962\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-47f0f85 elementor-widget elementor-widget-image\" data-id=\"47f0f85\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-content\/uploads\/elementor\/thumbs\/KIMWS4-21-p65pe0zfkqy6qaysr30ozc63iracof0kees4pgwqf6.png\" title=\"KIMWS4-21\" alt=\"KIMWS4-21\" class=\"elementor-animation-skew\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8a17311 elementor-widget elementor-widget-heading\" data-id=\"8a17311\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/research\/biomarkers\/\">Biomarkers<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da1c42f elementor-widget elementor-widget-text-editor\" data-id=\"da1c42f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Reliance on current measures of renal dysfunction, such as serum creatinine and blood urea nitrogen, has contributed to the slow translation of basic science discovery to therapeutically effective approaches in clinical practice.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea6c3ab elementor-widget elementor-widget-button\" data-id=\"ea6c3ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/research\/biomarkers\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-arrow-alt-circle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0383ce9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0383ce9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2ae8b07\" data-id=\"2ae8b07\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9d34a18 elementor-widget elementor-widget-heading\" data-id=\"9d34a18\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PUBLICATIONS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ef18f78 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ef18f78\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-57a648a\" data-id=\"57a648a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-302bb27 elementor-widget elementor-widget-heading\" data-id=\"302bb27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2021<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d509e0 elementor-widget elementor-widget-text-editor\" data-id=\"9d509e0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Schrauben SJ, Shou H, Zhang X, Anderson AH, <strong>Bonventre JV<\/strong>, Chen J, Coca S, Furth SL, Greenberg JH, Gutierrez OM, Ix JH, Lash JP, Parikh CR, Rebholz CM, Sabbisetti V, Sarnak MJ, Shlipak MG, Waikar SS, Kimmel PL, Vasan RS, Feldman HI, Schelling JR; CKD Biomarkers Consortium and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. <a href=\"https:\/\/doi.org\/10.1681\/ASN.2020040487\">Association of Multiple Plasma Biomarker Concentrations with Progression of Prevalent Diabetic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.<\/a> <span class=\"docsum-journal-citation full-journal-citation\">J Am Soc Nephrol. 2021 Jan;32(1):115-126. doi: 10.1681\/ASN.2020040487. Epub 2020 Oct 29. <\/span><span class=\"citation-part\">PMID: <span class=\"docsum-pmid\">33122288<\/span><\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a21ce94 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a21ce94\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6de3900\" data-id=\"6de3900\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eedcbc3 elementor-widget elementor-widget-heading\" data-id=\"eedcbc3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2020<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a22c110 elementor-widget elementor-widget-text-editor\" data-id=\"a22c110\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Ichimura T, Mori Y, Aschauer P, Padmanabha Das KM, Padera RF, Weins A, Nasr ML, <strong>Bonventre JV<\/strong>. <a href=\"http:\/\/10.1101\/2020.09.16.20190694\">KIM-1\/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney<\/a>. medRxiv. 2020 Sep 18:2020.09.16.20190694. doi: 10.1101\/2020.09.16.20190694. Preprint. PMID: 32995803<\/li><\/ul><div>\u00a0<\/div><ul><li>Solerte SB, D&#8217;Addio F, Trevisan R, Lovati E, Rossi A, Pastore I, Dell&#8217;Acqua M, Ippolito E, Scaranna C, Bellante R, Galliani S, Dodesini AR, Lepore G, Geni F, Fiorina RM, Catena E, Corsico A, Colombo R, Mirani M, De Riva C, Oleandri SE, Abdi R, <strong>Bonventre JV<\/strong>, Rusconi S, Folli F, Di Sabatino A, Zuccotti G, Galli M, Fiorina P. <a style=\"background-color: #ffffff;\" href=\"https:\/\/doi.org\/10.2337\/dc20-1521\">Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective, Observational Study.<\/a> Diabetes Care. 2020 Dec;43(12):2999-3006. doi: 10.2337\/dc20-1521. Epub 2020 Sep 29. PMID: 32994187<\/li><\/ul><div>\u00a0<\/div><ul><li><p>Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, Gootkind E, Park G, Hardcastle M, St John A, Appleman L, Chiu ML, Fialkowski A, De la Flor D, Lima R, Bordt EA, Yockey LJ, D&#8217;Avino P, Fischinger S, Shui JE, Lerou PH, <strong>Bonventre JV<\/strong>, Yu XG, Ryan ET, Bassett IV, Irimia D, Edlow AG, Alter G, Li JZ, Fasano A. <a href=\"https:\/\/doi.org\/10.1016\/j.jpeds.2020.08.037\">Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses.<\/a> J Pediatr. 2020 Dec;227:45-52.e5. doi: 10.1016\/j.jpeds.2020.08.037. Epub 2020 Aug 20. PMID: 32827525<\/p><\/li><li><p>Pereira Cabral B, <strong>Bonventre JV,<\/strong> Wieringa F, Mota FB. <a href=\"http:\/\/10.1111\/aor.13784\">Probing expert opinions on the future of kidney replacement therapies.<\/a> Artif Organs. 2020 Jul 22. doi: 10.1111\/aor.13784. Online ahead of print. PMID: 32697860<\/p><\/li><li><p>Wilflingseder J, Willi M, Lee HK, Olauson H, Jankowski J, Ichimura T, Erben R, Valerius MT, Hennighausen L, <strong>Bonventre JV<\/strong>. <a href=\"https:\/\/www.nature.com\/articles\/s41467-020-17205-5\">Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury.<\/a> Nat Commun. 2020 Jul 7;11(1):3383. doi: 10.1038\/s41467-020-17205-5. PMID: 32636391<\/p><\/li><li><p>Battistone MA, Mendelsohn AC, Spallanzani RG, Allegretti AS, Liberman RN, Sesma J, Kalim S, Wall SM, <b>Bonventre JV<\/b>, Lazarowski ER, Brown D, Breton S. <a href=\"http:\/\/10.1172\/JCI134791\">Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.<\/a> J Clin Invest. 2020 Jul 1;130(7):3734-3749. doi: 10.1172\/JCI134791. PMID: 32287042<\/p><\/li><li><p>Greenberg JH, Abraham AG, Xu Y, Schelling JR, Feldman HI, Sabbisetti VS, Gonzalez MC, Coca S, Schrauben SJ, Waikar SS, Ramachandran VS, Shlipak MG, Warady B, Kimmel PL, <b>Bonventre JV<\/b>, Denburg M, Parikh CR, Furth S; CKD Biomarkers Consortium. <a href=\"http:\/\/10.1681\/ASN.2019070723\">Plasma Biomarkers of Tubular Injury and Inflammation Are Associated with CKD Progression in Children.<\/a> J Am Soc Nephrol. 2020 May;31(5):1067-1077. doi: 10.1681\/ASN.2019070723. Epub 2020 Mar 31. PMID: 32234829<\/p><\/li><li><p>Yu SM, <b>Bonventre JV<\/b>. <a href=\"http:\/\/10.1097\/MNH.0000000000000605\">Acute kidney injury and maladaptive tubular repair leading to renal fibrosis.<\/a> Curr Opin Nephrol Hypertens. 2020 May;29(3):310-318. doi: 10.1097\/MNH.0000000000000605. PMID: 32205583<\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8bcc7f elementor-widget elementor-widget-button\" data-id=\"a8bcc7f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/publications\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-arrow-alt-circle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">All Publications<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bd0b433 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bd0b433\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-69bcdb8\" data-id=\"69bcdb8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1c234ef elementor-widget elementor-widget-heading\" data-id=\"1c234ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">NEWS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dd62ef9 elementor-widget elementor-widget-button\" data-id=\"dd62ef9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/news\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-arrow-alt-circle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">More News<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>THE LAB The Bonventre Lab is dedicated to rigorous, interdisciplinary research to create innovative technologies and treatments in the fight against kidney \u00a0disease, \u00a0and to uncovering the mechanisms and \u00a0pathologies \u00a0involved in kidney injury and repair. \u00a0Led by Joseph V Bonventre, MD, PhD, a world leader in nephrology for over 40 years, the lab fosters [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-396","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-json\/wp\/v2\/pages\/396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-json\/wp\/v2\/comments?post=396"}],"version-history":[{"count":309,"href":"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-json\/wp\/v2\/pages\/396\/revisions"}],"predecessor-version":[{"id":3962,"href":"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-json\/wp\/v2\/pages\/396\/revisions\/3962"}],"wp:attachment":[{"href":"https:\/\/bonventrelab.bwh.harvard.edu\/wordpress\/wp-json\/wp\/v2\/media?parent=396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}